피페라진 디하이드로클로라이드
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피페라진 디하이드로클로라이드 속성
- 녹는점
- 320°C(dec.)(lit.)
- 끓는 점
- 262.01°C (rough estimate)
- 밀도
- 1.3011 (rough estimate)
- 굴절률
- 1.6300 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 에 용해됨물
- 물리적 상태
- 백색 결정성 고체
- 색상
- 흰색에서 황백색까지
- InChI
- InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H
- InChIKey
- CVVIJWRCGSYCMB-UHFFFAOYSA-N
- SMILES
- C1NCCNC1.Cl.Cl
- LogP
- -1.171 (est)
- CAS 데이터베이스
- 142-64-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-42/43 | ||
안전지침서 | 22-26-36/37 | ||
OEB | B | ||
OEL | TWA: 5 mg/m3 | ||
RTECS 번호 | TL4025000 | ||
F 고인화성물질 | 3-10 | ||
HS 번호 | 2933599550 | ||
유해 물질 데이터 | 142-64-3(Hazardous Substances Data) | ||
독성 | mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967. | ||
기존화학 물질 | KE-05-1047 |
피페라진 디하이드로클로라이드 C화학적 특성, 용도, 생산
용도
Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.일반 설명
White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).반응 프로필
PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.잠재적 노출
Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.Carcinogenicity
Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.Purification Methods
Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]비 호환성
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.피페라진 디하이드로클로라이드 준비 용품 및 원자재
원자재
준비 용품
N-메틸피페라진
1-(2-피리딘-2-일-에틸)-피페라진
2-(4-BENZYLPIPERAZINO)BENZALDEHYDE
피페라진
6,7,9,10,17,18,20,21-옥타히드로디벤조(베타,카파)(1,4,7,10,13,16) 헥사옥사시클로옥타디신
1-하이드록시에틸에톡시피페라진
1,4-피페라진디카르보닐클로라이드
1-(4-메톡시벤질)피페라진
Dibenzo-24-crown-8
N-메틸-D3-피페라진
1-(4-CHLOROBENZYL)PIPERAZINE
붕산트리메틸
Ethyl N-piperazinecarboxylate
아세트아미드,2-[2-(1-피페라지닐)에톡시]-(9CI)
피페라진 디하이드로클로라이드 공급 업체
글로벌( 187)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 |
info@chemsigma.com | China | 1342 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24099 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
Alfa Chemistry | |
info@alfa-chemistry.com | United States | 2344 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
피페라진 디하이드로클로라이드 관련 검색:
1-(2,3,4-트리메톡시벤질)피페라진 디하이드로클로라이드 벤질피페라진 트리플루오페라진 디하이드로클로라이드 2-(1-피페라지닐)피리미딘 트리포린 히드록시진 수화염화물
Diethyl azodicarboxylate
4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid
1,1,3,3-Tetramethylurea
1-Hydroxybenzotriazole
Olaparib Impurity 14
5-Bromo-2-fluorobenzonitrile
Cyclopropanecarbonyl Chloride
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile
2-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]-
Olaparib Impurity 31
Olaparib Impurity 30