ML216
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ML216 속성
- 밀도
- 1.583±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
- 산도 계수 (pKa)
- 6.40±0.50(Predicted)
- 물리적 상태
- 가루
- 색상
- 연한 주황색에서 진한 주황색까지
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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ML216 C화학적 특성, 용도, 생산
개요
Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-용도
ML216 has been used in cell proliferation assays.Biochem/physiol Actions
ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.ML216 준비 용품 및 원자재
원자재
준비 용품
ML216 공급 업체
글로벌( 75)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 |
abby@arkpharm.com | CHINA | 3279 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Chemtour Biotech Co., Ltd | +8617327281506 |
market@chemtour.com | China | 1472 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131981 | 58 |