6-메톡시-1-테트라론
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6-메톡시-1-테트라론 속성
- 녹는점
- 77-79 °C (lit.)
- 끓는 점
- 171 °C/11 mmHg (lit.)
- 밀도
- 1.0558 (rough estimate)
- 굴절률
- 1.5250 (estimate)
- 인화점
- 171°C/11mm
- 저장 조건
- Sealed in dry,Room Temperature
- 물리적 상태
- 미세 결정성 분말
- 색상
- 노란색에서 밝은 갈색까지
- 수소이온지수(pH)
- 5.96 at 23℃ and 10g/L
- Merck
- 14,6000
- BRN
- 972739
- InChIKey
- MNALUTYMBUBKNX-UHFFFAOYSA-N
- CAS 데이터베이스
- 1078-19-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
안전지침서 | 24/25-36-26 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29145000 |
6-메톡시-1-테트라론 C화학적 특성, 용도, 생산
화학적 성질
yellow to light brown fine crystalline powder용도
6-Methoxy-1-tetralone is a reagent useful in the synthesis of (2-(furanyl)vinyl)-1-tetralone chalcones which possesses anticancer agents and inducers of apoptosis.제조 방법
(1) Reacting anisole with an acylating agent in Lewis acid and a solvent at the temperature of-10-40 ℃ to generate an intermediate 1, wherein the molar ratio of the Lewis acid to the acylating agent to the anisole is 1-10: 1-10: 1, the Lewis acid is selected from one or more of concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminum trichloride, superacid and heteropoly acid;(2) the intermediate 1 does not need to be separated, the temperature is raised to 70-120 ℃, and the intermediate 1 continues to react to generate 6-methoxy-1-tetralone;
(3) cooling the reaction product, adding water to stop the reaction, extracting, purifying and desolventizing to obtain a crude product of the 6-methoxy-1-tetralone, and refining the crude product by a solvent to obtain a high-purity product.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 94, 1942 DOI: 10.1021/ja01253a025Tetrahedron Letters, 9, p. 2917, 1968 DOI: 10.1016/S0040-4039(00)89611-2
Synthesis
The synthesis of 6-methoxy-1-tetralone is as follows:Eaton's reagent (1.00 mL, 5.31 mmol) was added slowly to a stirred solution of methyl 4-(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) in DCE (1 mL). The resulting mixture was stirred at 75 °C for 2h under N2 atmosphere. Then, the reaction mixture was allowed to reach room temperature, and was poured over ice-water and extracted with EtOAc (3 × 15 mL). The combined organic extracts were washed successively with brine (2 × 15 mL) and H2O (2 × 20 mL), filtered over Na2SO4 and concentrated under reduced pressure. The resulting brownish oil was fractionated by column chromatography (silica gel, EtOAc-hexanes, 1:9) to obtain 6-methoxy-1-tetralone as ayellowish oil; yield: 0.28 g (91%).6-메톡시-1-테트라론 준비 용품 및 원자재
원자재
준비 용품
17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether
3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal
17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal
3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal
6-CYANO-1-TETRALONE
6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one
4-Methoxyphthalic acid
2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one
2-[2-(6-methoxytetralin-1-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione
1-CHLORO-6-METHOXY-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE
7-METHOXY-4,5-DIHYDRO-NAPHTHO[1,2-D]THIAZOL-2-YLAMINE
6-메톡시-1-테트라론 공급 업체
글로벌( 418)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing Triumpharm Co.,Ltd | +86-02586182925 +86-15105172550 |
info@triumpharm.com | China | 129 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 6992 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2967 | 58 |
6-메톡시-1-테트라론 관련 검색:
트리플르오르메톡시벤젠 테트라히드로나프탈렌 6-메톡시-1-테트라론
Nabumetone
1-Tetralone
2-Bromo-6-methoxynaphthalene
6-Methoxy-2-naphthaldehyde
7-Methoxy-1-tetralone
6,7-Dimethoxy-1-tetralone
7-Methoxy-2-tetralone
6,7-Dimethoxy-2-tetralone
5-Methoxy-3,4-dihydro-2H-naphthalen-1-one
5 8-DIMETHOXY-1-TETRALONE 99
5-Methoxy-2-tetralone
6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE
dactylocycline B
6-METHOXY-2-METHYL-1-TETRALONE
6,7-(METHYLENEDIOXY)-1-TETRALONE