Cabergoline
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Cabergoline 속성
- 녹는점
- 102-104°C
- 밀도
- 1.156±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥10mg/mL
- 산도 계수 (pKa)
- 13.05±0.46(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- optical activity
- [α]/D 61 to 68°, c = 0.5 in dichloromethane
- 안정성
- 흡습성
- InChIKey
- KORNTPPJEAJQIU-KJXAQDMKSA-N
- SMILES
- [C@]12([H])C[C@H](CN(CC=C)[C@]1([H])CC1=CNC3C=CC=C2C1=3)C(=O)N(CCCN(C)C)C(=O)NCC |&1:0,3,9,r|
- CAS 데이터베이스
- 81409-90-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36/37 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | KE6167600 | ||
| HS 번호 | 2939690000 | ||
| 독성 | Sol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla) |
Cabergoline C화학적 특성, 용도, 생산
개요
Cabergoline is a potent, selective, and long-lasting dopamine D2 receptor agonist launched in 1993 in Belgium as a prolactin inhibitor. A single 1 mg dose of cabergoline effectively prevents puerperal lactation for up to 14 days, remarkably superior to other drugs that require a daily regimen. It has a low rate of rebound breast activity and good tolerability. Cabergoline is also in clinical trials for Parkinson's disease, breast cancer, and hyperprolactinaemia.화학적 성질
White Crystalline Solid용도
Cabergoline is an ergot derivative and a dopamine D2-receptor agonist (1,2,3). It inhibits the secretion of prolactin and growth hormone.정의
ChEBI: An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.일반 설명
Cabergoline, (6aR,9R,10aR)-7-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide (Dostinex), is a white powder soluble inalcohol, chloroform, and N,N-dimethylformamide; slightlysoluble in acidic solutions and in n-hexane; and insoluble inwater. Following oral administration, peak plasma concentrationsare reached within 2 to 3 hours. Cabergoline ismoderately bound to plasma proteins in a concentrationindependentmanner. The absolute bioavailability of cabergolineis unknown. Cabergoline is extensively metabolizedby the liver, predominantly via hydrolysis of the acylureabond of the urea moiety. CYP450 metabolism appears to beminimal. The major metabolites identified thus far do not contribute to the therapeutic effect of cabergoline. Lessthan 4% is excreted unchanged in the urine. Fecal excretionrepresents the main route of cabergoline elimination. Thereare no reports of interactions of cabergoline with other antiparkinsonianagents. Clarithromycin may elevate theplasma concentration of cabergoline by the inhibition ofboth CYP3A4 and P-glycoprotein.Cabergoline is a potentD2 receptor agonist and is indicated for the treatment ofhyperprolactinemic disorders, either idiopathic or causedby pituitary adenomas.생물학적 활성
Selective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 and 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.Cabergoline 준비 용품 및 원자재
원자재
3-METHOXYPROPIONIC ACID
Diimine
푸란
수산화나트륨
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Desethylcarbamoyl Cabergoline
Des-N-allylcabergoline
(82)-N-[[[3-(Dimethylamino)propyl]amino]carbonyl]-N-ethyl-6-(2-propen-1-yl)-ergoline-8-carboxamide
6-Allyl-8beta-carboxyergoline
에틸이소시아네이트
N'-(에틸카본이미도일)-N,N-디메틸1,3-프로판디아민 모노염산염
준비 용품
Cabergoline 공급 업체
글로벌( 318)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 |
info@dmksw.xin | China | 723 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| HEBEI Meijinnong Import And Export Trade Co.,LTD | +8617363028569 |
admin@mjn-cn.com | China | 93 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 |
market02@senwayer.com | China | 874 | 58 |
| Hebei Ningnan Trade Co. LTD | +86-18034019111 |
admin@hbningnan.com | China | 278 | 58 |
| Hebei Shengyuan Jinlong Import and Export Co. LTD | +8617367750398 |
info@hebeisyjl.com | China | 1867 | 58 |
| Anhui Yisheng Technology Co., LTD | +86-19355901310 +86-19355901310 |
alice@ah-yisheng.com | China | 333 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 |
ada@sh-teruiop.com | China | 893 | 58 |
Cabergoline 관련 검색:
(8β)-10-메톡시-1,6-디메틸에르고린-8-메탄올-5-브로모-3-피리딘카복실 에스테르 알릴글리시딜에테르 N,N-다이메틸폼아마이드 부틸산메틸에스테르 몰식자산프로필 알릴벤젠 N""-[3-(디메틸아미노)프로필]-N,N-디메틸프로판-1,3-디아민 알릴 알코올
CABERGOLINE-D5
ergotamine
NIPECOTAMIDE
2,6,10-TRIMETHYL-2,6,10-TRIAZAUNDECANE
1H-Indole, 4-(3-piperidinyl)-, (R)-
N,N-DIMETHYL-3-PIPERIDINECARBOXAMIDE
PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE
N-ethylpiperidine-3-carboxamide
Cabergoline
Cabergoline internal Spec