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3-히드록시-1,2-디메틸-4(1H)-피리돈

3-히드록시-1,2-디메틸-4(1H)-피리돈
3-히드록시-1,2-디메틸-4(1H)-피리돈 구조식 이미지
카스 번호:
30652-11-0
한글명:
3-히드록시-1,2-디메틸-4(1H)-피리돈
동의어(한글):
3-히드록시-1,2-디메틸-4(1H)-피리돈
상품명:
Deferiprone
동의어(영문):
L1;DMHP;CP20;Kelfer;DEFERIDONE;DEFERIPRON;DEFERIPRONE;deferiprone(DFP);TIMTEC-BB SBB006753;cp20(chelatingagent)
CBNumber:
CB0308124
분자식:
C7H9NO2
포뮬러 무게:
139.15
MOL 파일:
30652-11-0.mol

3-히드록시-1,2-디메틸-4(1H)-피리돈 속성

녹는점
272-275 °C(lit.)
끓는 점
255.1°C (rough estimate)
밀도
1.1997 (rough estimate)
굴절률
1.4800 (estimate)
저장 조건
-20°C Freezer
물리적 상태
Crystalline Powder or Needles
산도 계수 (pKa)
pKa1 3.3, pKa2 9.7(at 25℃)
색상
White to off-white
수용성
Soluble in hot water
Merck
14,2859
InChIKey
TZXKOCQBRNJULO-UHFFFAOYSA-N
CAS 데이터베이스
30652-11-0(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-36/37/38
안전지침서 26-36-37/39
WGK 독일 3
RTECS 번호 UU7785940
HS 번호 29333990
독성 LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:

3-히드록시-1,2-디메틸-4(1H)-피리돈 C화학적 특성, 용도, 생산

개요

Deferiprone, the first oral iron chelator, was marketed in India for the management of thalassaemia. Patients with thalassaemia, a blood related genetic disorder, require life time transfusion which causes excessive deposition of iron in liver and spleen, subsequent damage to organs and eventually death unless iron is removed by a chelator. Deferiprone is a potent iron chelator that mobilizes excessive iron from iron storage proteins ferritin and hemosiderin, from iron saturated transferrin and lactoferrin, but not from hemoglobin. The deferiprone-iron complex is excreted in urine and bile. Deferiprone was reportedly well accepted by patients and no hematological toxicity was observed. Deferiprone has also been demonstrated as an effective and safe chelator in the mobilization of aluminum.

화학적 성질

White Needles

Originator

Cipla (India)

용도

A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro

용도

iron chelating agent

정의

ChEBI: A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.

상표명

Kelfer

3-히드록시-1,2-디메틸-4(1H)-피리돈 준비 용품 및 원자재

원자재

준비 용품


3-히드록시-1,2-디메틸-4(1H)-피리돈 공급 업체

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