ChemicalBook >제품 카탈로그 >제약 중간체>헤테로 사이 클릭 화합물>피리딘 화합물>히드 록시 피리딘>3-히드록시-1,2-디메틸-4(1H)-피리돈

3-히드록시-1,2-디메틸-4(1H)-피리돈

3-히드록시-1,2-디메틸-4(1H)-피리돈 구조식 이미지

카스 번호:: 30652-11-0

한글명:: 3-히드록시-1,2-디메틸-4(1H)-피리돈

동의어(한글):: 3-히드록시-1,2-디메틸-4(1H)-피리돈

상품명:: Deferiprone

동의어(영문):: L1;CP20;DMHP;Kelfer;DEFERIPRON;DEFERIDONE;eferiprone;DEFERIPRONE;Deferiprone CRS;deferiprone(DFP)

CBNumber:: CB0308124

분자식:: C7H9NO2

포뮬러 무게:: 139.15

MOL 파일:: 30652-11-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 318

3-히드록시-1,2-디메틸-4(1H)-피리돈 속성

녹는점: 272-275 °C (lit.)

끓는 점: 255.1°C (rough estimate)

밀도: 1.1997 (rough estimate)

굴절률: 1.4800 (estimate)

저장 조건: 2-8°C

용해도: 물에 용해됩니다(가온 시 최대 5mg/ml).

물리적 상태: 결정질 분말 또는 바늘

산도 계수 (pKa): pKa1 3.3, pKa2 9.7(at 25℃)

색상: 흰색에서 황백색까지

수용성: 뜨거운 물에 용해됨

Merck: 14,2859

안정성: 제공된 대로 구매일로부터 1년 동안 안정적입니다. 용액은 안정적이지 않으므로 매일 새로 준비해야 합니다.

InChIKey: TZXKOCQBRNJULO-UHFFFAOYSA-N

CAS 데이터베이스: 30652-11-0(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22-36/37/38
안전지침서	26-36-37/39
WGK 독일	3
RTECS 번호	UU7785940
HS 번호	29333990
유해 물질 데이터	30652-11-0(Hazardous Substances Data)
독성	LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

NFPA 704

	0
2		0

3-히드록시-1,2-디메틸-4(1H)-피리돈 C화학적 특성, 용도, 생산

개요

Deferiprone is a lipophilic iron chelator that binds to iron at a molar ratio of 3:1 (ligand: iron). Its active form is available orally, making it the only oral iron chelator. Deferiprone is a member of the 4-pyridone family and is a pyridine 4-4 (1H) -one, with a methyl substitution at positions 1 and 2 and a hydroxyl substitution at position 3. By binding to iron, Deferiprone can remove excess iron from the body and prevent serum iron overload in patients with transfusion-dependent thalassemia. It has chelation and protective effects and is primarily used to treat thalassaemia.

화학적 성질

White Needles

용도

A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro

정의

ChEBI: Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.

일반 설명

3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative.It reacts with uranyl salts [UO₂(NO₃)₂] in aqueous acidic solution to afford mono nuclear complexes ([UO₂(dpp)(Hdpp)₂(H₂O)]ClO₄). X-ray studies have been conducted to examine the structure and geometry of these complexes.

3-히드록시-1,2-디메틸-4(1H)-피리돈 준비 용품 및 원자재

원자재

4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-, acetate (1:1) 3-(benzyloxy)-1,2- dimethylpyridin-4(1H)-one 1-(3-hydroxy-2-furyl)ethanone 메틸아민 3-(BENZYLOXY)-2-METHYL-4H-PYRAN-4-ONE 말톨 철분 Galactosylisomaltol 메틸아민 하이드로클로라이드 아세트산(빙초산)

준비 용품

D-glucose

3-히드록시-1,2-디메틸-4(1H)-피리돈 공급 업체

글로벌( 318)공급 업체

공급자	전화	이메일	국가	제품 수	이점
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hainan Xiyuan Chemical Technology Co., Ltd.	+86-15008981366	15008981366@163.com	CHINA	9	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58

3-히드록시-1,2-디메틸-4(1H)-피리돈 관련 검색:

3-피리딘올 3-히드록시-1,2-디메틸-4(1H)-피리돈 4-HYDROXYPYRIDINE 1-BENZYL-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-NITROBENZYL)-4(1H)-PYRIDINONE 1-(2-CHLORO-6-FLUOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-1-(4-METHYLBENZYL)-4(1H)-PYRIDINONE 1-(3,4-DICHLOROBENZYL)-3-[(2,6-DICHLOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-(BENZYLOXY)-1-(2-CHLORO-6-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(4-CHLOROBENZYL)OXY]-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-METHYL-4(1H)-PYRIDINONE 1-BENZYL-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 1-(4-CHLOROBENZYL)-3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-4(1H)-PYRIDINONE 3-[(2,6-DICHLOROBENZYL)OXY]-1-(4-FLUOROBENZYL)-2-METHYL-4(1H)-PYRIDINONE 3-[(2-CHLORO-6-FLUOROBENZYL)OXY]-2-METHYL-1-(3-NITRO-2-PYRIDINYL)-4(1H)-PYRIDINONE