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BL-8040

BL-8040 구조식 이미지
카스 번호:
664334-36-5
상품명:
BL-8040
동의어(영문):
BKT140;BL-8040;TF14016;Motixafortide;BKT140 (BL-8040);4F-Benzoyl-TN14003;BKT140CXCR4 antagonist;BKT140 4-fluorobenzoyl;BKT140,BL-8040,TF14016,4F-Benzoyl-TN14003, >99%
CBNumber:
CB03152184
분자식:
C97H144FN33O19S2
포뮬러 무게:
2159.5193632
MOL 파일:
664334-36-5.mol

BL-8040 속성

밀도
1.52±0.1 g/cm3(Predicted)

안전

BL-8040 C화학적 특성, 용도, 생산

효소 저해제

This orally bioavailable, disulfide cross-linked, polyphemusin-II-derived peptide antagonist (sequence shown above, with Nal = naphthylamine, Cit = citrulline, D-Lys = D-Lysine, and Cys = half-cystine), also known as 4-Fbenzoyl-TN14003 and BL-8040, targets CXC Chemokine Receptor-4 (CXCR4), a G-protein-coupled receptor that is directly involved in tumor progression, tumor angiogenesis, metastasis, and cancer cell survival. Primary Mode of Inhibitory Action: CXCR4 is over-expressed in more than 70% of human cancers and its expression often correlates with disease severity. BKT140 exhibits high affinity (Ki = 0.8nM) and a low rate of dissociation from its receptor. BKT140 prevents the binding of stromal derived factor-1 (SDF-1 or CXCL12) to CXCR4 activation, resulting in decreased tumor cell proliferation and migration. In addition, inhibition of CXCR4 may mobilize hematopoietic cell egress from the bone marrow and into blood. BKT140 significantly and preferentially stimulates multiple myeloma apoptotic cell death, as indicated by induced morphological changes, phosphatidylserine externalization, decreased mitochondrial membrane potential, caspase-3 activation, sub-G1 cell-cycle arrest, as well as DNA double-stranded breaks.

BL-8040 준비 용품 및 원자재

원자재

준비 용품


BL-8040 공급 업체

글로벌( 16)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24686 60
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 814 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20537 58
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29611 58
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4788 58
Wuxi Zhongkun Biochemical Technology Co., Ltd. 18013409632
051085625359 sales@reading-chemicals.com; China 15202 58
Novachemistry +44 (0)208 191 7890
+44 (0)203 637 6965 info@novachemistry.com United Kingdom 3797 58
Chengdu Youngshe Chemical Co., Ltd. 17380623303 028-62328193-
Caroline@youngshechem.com China 1649 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919
0571-87213919 Ellis@peptidego.com China 2174 58
Hangzhou Guangyuan Biotechnologies Co.,LTD 18989848203
services@raystarbio.com China 6961 58

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