독세핀염산염
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독세핀염산염 속성
- 녹는점
- 187-189°C
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- 1M HCl: 50mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물(100mM), 클로로포름(1:2), 알코올(1:1), 메탄올 및 DMSO에 용해됩니다.
- 최대 파장(λmax)
- 298nm(lit.)
- Merck
- 14,3435
- 안정성
- -20°C의 냉동고에 보관하세요
- InChIKey
- MHNSPTUQQIYJOT-SJDTYFKWSA-N
- CAS 데이터베이스
- 1229-29-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 25-39/23/24/25-23/24/25-11 | ||
안전지침서 | 36/37/39-45-36/37-16 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | HQ4375000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29329990 | ||
독성 | LD50 oral in rat: 147mg/kg | ||
기존화학 물질 | KE-09888 |
독세핀염산염 C화학적 특성, 용도, 생산
개요
Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively). It is a histamine H1 receptor antagonist (Ki = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.화학적 성질
White Solid용도
Doxepin hydrochloride is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.It is a antidepressant used clinically to treat anxiety and depression.Indications
Doxepin (Sinequan, Adapin) is a tricyclic antidepressant with potent H1 and H2 antagonistic effects. It also has antimuscarinic, antiserotonic, and anti-α-adrenergic activity. Use of 10 to 50 mg PO t.i.d. to q.i.d. has been shown to be effective in the treatment of primary acquired, chronic idiopathic urticaria, idiopathic cold urticaria, and for patients with anxiety or depression associated with their urticaria. Sedation and dry mouth are the most common side effects. Doxepin may interact with other drugs that are metabolized by the cytochrome P-450 system (ketoconazole, itraconazole, erythromycin, clarithromycin, etc.).일반 설명
Doxepin, 3-dibenz[b,e]-oxepin-11(6H)ylidine-N,N-dimethyl-1-propanamine hydrochloride, N,N-dimethyl-3-(dibenz[b,e]oxepin-11(6H)-ylidene)propylamine (Sinequan, Adapin), isan oxa congener of amitriptyline, as can be seen from itsstructure.The oxygen is interestingly placed and should influenceoxidative metabolism as well as postsynaptic and presynapticbinding affinities. The (Z)-isomer is the more active, althoughthe drug is marketed as the mixture of isomers. Thedrug overall is a NE and 5-HT reuptake blocker with significantanticholinergic and sedative properties. It can be anticipatedthat the nor- or des- metabolite will contribute to theoverall activity pattern.
독세핀염산염 준비 용품 및 원자재
원자재
부틸리튬
디메틸아민
트리페닐포스핀
브롬화수소
10-클로로-10,11-디하이드로-디벤즈(b,f)티에핀
Benzoic acid, 2-(phenoxymethyl)-, methyl ester
11-(3-Bromopropylidene)-6,11-dihydrodibenzo[b,e]oxepine
Dibenz[b,e]oxepin-11-ol, 11-[3-(1,1-dimethylethoxy)propyl]-6,11-dihydro-
2-(히드록시메틸)벤조산
2-(페녹시메틸)벤조산
(E)-11-(3-chloropropylidene)-6,11-dihydrodibenzo[b,e]oxepine
클로로[3-(디메틸아미노)프로필]마그네슘
디벤즈[b,e]옥세핀-11(6H)-온
페놀
Methyl 2-chloromethylbenzoate
프탈이드
o-프탈알데히드
준비 용품
독세핀염산염 공급 업체
글로벌( 383)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Hebei shuoxi biotechnology co. LTD | +8613081092107 |
CHINA | 968 | 58 | |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Hebei Binshare New Material Co. Ltd | +8618633865755 |
china01@hbbinshare.com | CHINA | 969 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
독세핀염산염 관련 검색:
1-AdaMantanethylaMine
Topotecan hydrochloride
Buflomedil hydrochloride
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
Tramadol hydrochloride
DOXEPIN
D/L-AMPHETAMINE HYDROCHLORIDE
Sibutramine hydrochloride
DOXEPIN HYDROCHLORIDE - REFERENCE SPECTRUM
(E)-Doxepin hydrochloride
DESMETHYLDOXEPIN
11[6H]-[3-(METHYLAMINO)PROPYLIDENE]DIBENZ[B,E]OXEPINE HYDROCHLORIDE
Doxepin hydrochloride
DOXEPIN INTERMEDIATES
(Z)-Doxepin hydrochloride
DOXEPIN HYDROCHLORIDE [N-METHYL-3H]