N-아이오도석신이미드
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N-아이오도석신이미드 속성
- 녹는점
- 202-206 °C(lit.)
- 끓는 점
- 249.6±23.0 °C(Predicted)
- 밀도
- 2,245 g/cm3
- 저장 조건
- 2-8°C
- 용해도
- 디옥산, 테트라히드로푸란 및 아세토니트릴에 용해됩니다. 에테르와 사염화탄소에 불용성.
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- -2.57±0.20(Predicted)
- 색상
- 흰색-노란색에서 갈색까지
- 수용성
- 물에서 분해되다
- 감도
- Moisture Sensitive
- Merck
- 14,5045
- BRN
- 113917
- 안정성
- 수분에 민감한
- InChIKey
- LQZMLBORDGWNPD-UHFFFAOYSA-N
- CAS 데이터베이스
- 516-12-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38 | ||
안전지침서 | 26-36-37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | WN2817000 | ||
F 고인화성물질 | 8-9 | ||
위험 참고 사항 | Harmful/Keep Cold/Moisture Sensitive | ||
TSCA | No | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29251995 |
N-아이오도석신이미드 C화학적 특성, 용도, 생산
화학적 성질
white-yellow to brown crystalline powder용도
N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis.정의
ChEBI: N-iodosuccinimide is a five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom. It is a dicarboximide and a pyrrolidinone. It derives from a succinimide.제조 방법
To a solution of 39.2g of succinimide in 1200ml of boiling water was added 51.0g of freshly precipitated silver oxide, the mixture was filtered and the silver salt was allowed to crystallize. Filtration and washing with cold water furnished 45.0g of the silver salt of succinimide suitable for the iodination step.The finely powdered salt (49.5g) was added in portions with stirring to a solution of 50.8g of iodine in 300ml of acetone, the temperature being maintained at 5-10°C. After decolorization (30 min.), the silver iodide was filtered, the solvent was removed under reduced pressure at room temperature and the residue was washed with ether, yielding 43g of N-iodosuccinimide with mp 189-191°C. An analytical sample (85% recovery) was obtained by dissolving in the minimum quantity of hot dioxane and precipitating with carbon tetrachloride; colorless needles, mp 200-201°C.
Ref: JACS 75, 3493 (1953)
화학 반응
N-Iodosuccinimide (NIS) is an iodinating agent that is used for various electrophilic iodinations and as source for iodine in radical reactions.N-Iodosuccinimide is the least reactive of the N-haloamides in aromatic substitution. N-Iodosuccinimide does not act as an iodinating agent in pure dimethyl sulfoxide or N-ethylacetamide. On the other hand, butyl disulfide and a number of other sulfur-containing compounds are effective catalysts at low concentration for the iodination of guanosine derivatives using N-iodosuccinimide. This catalytic effect is observed when dimethyl sulfoxide is used as the solvent,but not when N-ethylacetamide is used.
https://www.organic-chemistry.org/chemicals/oxidations/n-iodosuccinimide-nis.shtm
Purification Methods
Crystallise it from dioxane/CCl4. It iodinates arenes in triflic acid. [Olah et al J Org Chem 58 3194 1993, Beilstein 21/9 V 544.]N-아이오도석신이미드 준비 용품 및 원자재
원자재
준비 용품
N-아이오도석신이미드 공급 업체
글로벌( 624)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 |
alice@jndxj.com | China | 309 | 58 |
Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 |
sales1@nuowei-chem.com | China | 1642 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 |
hbjbtech@163.com | China | 1000 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 |
admin@hbsaisier.cn | China | 565 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 738 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15371 | 58 |