ChemicalBook >제품 카탈로그 >생화학 공학>아미노산과 유도체>히스티딘 유도체>Boc-His(Trt)-OH

Boc-His(Trt)-OH

Boc-His(Trt)-OH 구조식 이미지

카스 번호:: 32926-43-5

상품명:: Boc-His(Trt)-OH

동의어(영문):: BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE;N-Boc-N'-trityl-L-histidine

CBNumber:: CB0342634

분자식:: C30H31N3O4

포뮬러 무게:: 497.58

MOL 파일:: 32926-43-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 218

Boc-His(Trt)-OH 속성

녹는점: ~130 °C (dec.)

알파: 12.5 º (C=1% IN MEOH)

끓는 점: 667.5±55.0 °C(Predicted)

밀도: 1.16±0.1 g/cm3(Predicted)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 3.17±0.10(Predicted)

색상: 흰색에서 황백색까지

optical activity: [α]20/D +12.5±1.0°, c = 1% in methanol

BRN: 732035

InChIKey: OYXZPXVCRAAKCM-SANMLTNESA-N

SMILES: C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O

CAS 데이터베이스: 32926-43-5(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3
HS 번호	29224999

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고		P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

Boc-His(Trt)-OH C화학적 특성, 용도, 생산

화학적 성질

White to off white powder

용도

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

용도

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

주요 응용

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

제조 방법

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et₂O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH 준비 용품 및 원자재

원자재

준비 용품

Boc-His(Trt)-OH 공급 업체

글로벌( 218)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8618980456393	daisy@enlaibio.com	China	1369	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
AB PharmaTech,LLC	323-480-4688		United States	989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58

Boc-His(Trt)-OH 관련 검색:

파라-톨룰일산 L-(-) 히스티딘 트리틸클로라이드 펜옥심틸 페니실린 톨루엔 1-(트리페닐메틸)이미다졸 N-Carbobenzyloxyglycine Boc-Aib-OH Trityl candesartan cilexetil N-Boc-L-Histidine N-Boc-N'-Cbz-L-lysine N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine BOC-GLY-LEU-OH H-HIS(BZL)-OH BOC-HIS(BZL)-OH (-)-2-[METHYLAMINO]-1-PHENYLPROPANE