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할로퓨진원

할로퓨진원 구조식 이미지

카스 번호:: 55837-20-2

한글명:: 할로퓨진원

동의어(한글):: 7-브로모-6-클로로-3-[3-[(2R,3S)-3-히드록시-2-피페리질]-2-옥소프로필]-4(3H)-키나조리논;할로퓨진원;7-브로모-6-클로로-3-[3-[(2R,3S)-3-히드록시-2-피페리질]-2-옥소프로필]-4(3H)-키나조리논;할로푸지논

상품명:: Halofuginone

동의어(영문):: HAL;aPKC[l];trans-l);empostatin;HALOFUGINONE;HALOQUGINONE;2Halofuginone;Halofuginone, >97%;Halofuginone USP/EP/BP;Halofuginone Hydrochloride

CBNumber:: CB0361552

분자식:: C16H17BrClN3O3

포뮬러 무게:: 414.68

MOL 파일:: 55837-20-2.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 245

할로퓨진원 속성

녹는점: >150°C dec.

끓는 점: 595.8±60.0 °C(Predicted)

밀도: 1.73±0.1 g/cm3(Predicted)

저장 조건: Keep in dark place,Sealed in dry,Room Temperature

용해도: DMSO : 9 mg/mL (21.70 mM)

산도 계수 (pKa): 14.61±0.40(Predicted)

CAS 데이터베이스: 55837-20-2(CAS DataBase Reference)

안전

기존화학 물질	97-3-251

할로퓨진원 C화학적 특성, 용도, 생산

개요

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

화학적 성질

Off-White Solid

용도

Halofuginone is a halogenated derivative of febrigugine. It is Used as an antiprotozoal.

생물학적 활성

Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga. It has antimalarial and anticoccidial actions. In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells. Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models. This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response. This prevents the differentiation of TH17 cells, blunting an autoimmune response.

할로퓨진원 준비 용품 및 원자재

원자재

N,N-다이메틸폼아마이드 7-Bromo-6-chloro-4-quinazolinone

준비 용품

할로퓨진원 공급 업체

글로벌( 245)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

할로퓨진원 관련 검색:

2-히드록시퀴노린 드로페리돌, 펜타닐 할로겐화 히단토인 2,2,6,6-사메틸-4-피페리디놀 할로페리돌 트라조돈 클로로디플루오르메탄 브롬 할로퓨진원 CHLOROPHOSPHONAZO III Triacetonediamine Cefoperazone Cefoperazone sodium +sulbactam sodium(1:1/2:1) Pipecuronium bromide 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Diphenoxylate Halofuginone hydrobromide Halofuginone Lactate