1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
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1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE 속성
- 녹는점
- approximate 230℃ (dec.)
- 끓는 점
- 613.5±65.0 °C(Predicted)
- 밀도
- 1.536±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 용해성2mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 10.63±0.10(Predicted)
- 색상
- 흰색에서 밝은 갈색까지
- 수용성
- 증류수, DMSO(>5mg/ml), 투명(가온) 및 PBS pH 7.2(~0.15mg/ml)에 용해됩니다.
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. 증류수 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 94944-70-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE C화학적 특성, 용도, 생산
용도
Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.Biochem/physiol Actions
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE 준비 용품 및 원자재
원자재
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol hydrochloride
1,3-Dithiolane-2-carboxaldehyde, 2-methyl-
2-?Propenimidic acid, 2-?ethoxy-?, methyl ester
1-Amino-1-deoxy-D-fructose Acetate
alpha-Ethoxyacrylonitrile
D-글루코사민
메틸알콜
준비 용품
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE 공급 업체
글로벌( 57)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94838 | 76 |
| Alfa Aesar | 400-6106006 |
saleschina@alfa-asia.com | China | 30132 | 84 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 |
info@sagechem.com | China | 10269 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 |
sales@fartop.net | China | 2231 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 |
sales@chem-strong.com | China | 17982 | 56 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 |
greensnown@163.com | China | 9911 | 50 |