N-히드록시석신이미드
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N-히드록시석신이미드 속성
- 녹는점
- 95-98 °C(lit.)
- 끓는 점
- 215.33°C (rough estimate)
- 밀도
- 1.4769 (rough estimate)
- 증기압
- 0Pa at 25℃
- 굴절률
- 1.4080 (estimate)
- 저장 조건
- Store at +2°C to +8°C.
- 용해도
- DMSO(용해성), 메탄올(약간)에 용해됨
- 물리적 상태
- 액체 또는 고체
- 산도 계수 (pKa)
- 7.81±0.20(Predicted)
- 색상
- 투명한 황갈색~갈색
- 수소이온지수(pH)
- 5-7 (50g/l, H2O, 20℃)
- 수용성
- 녹는
- 감도
- Hygroscopic
- BRN
- 113913
- 안정성
- 안정적인. 강산화제, 산 염화물, 산 무수물, 강염기와 호환되지 않습니다. 습기로부터 보호하십시오.
- InChIKey
- NQTADLQHYWFPDB-UHFFFAOYSA-N
- LogP
- -2.01
- CAS 데이터베이스
- 6066-82-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 22-24/25-26-36 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29251995 | ||
기존화학 물질 | KE-20885 |
N-히드록시석신이미드 C화학적 특성, 용도, 생산
개요
N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source).
화학적 성질
White to pale yellow용도
N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.주요 응용
N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester
N-succinimidyl 3-iodobenzoate
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.
Additive used in the carbodiimide method for improved amidations and peptide couplings.
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.
Purification Methods
Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]N-히드록시석신이미드 준비 용품 및 원자재
원자재
숙신산무수물
염산 히드록실아민
NSC81536
estradiol-3-sulfate
1-Pyrrolidinecarboxylic acid, 2,5-dioxo-, 1,1-dimethylethyl ester
1-Hydroxypiperidine-2,6-dione
N-HYDROXYSUCCINIMIDYL-4-AZIDOBENZOATE
디(N-숙신이미딜)카보네이트
N-(3-aminopropyl)benzamide
BZ-OSU
(카르복실메틸)트리메틸암모늄 클로라이드 하이드라지드
N-Succinimidyl 3-maleimidopropionate
2-METHYLBUTYLAMINE
준비 용품
N-히드록시석신이미드 공급 업체
글로벌( 857)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 |
prisun@prisunpharma.com | China | 215 | 58 |
Chemtour Biotech Co., Ltd | +8617327281506 |
market@chemtour.com | China | 1472 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
N-히드록시석신이미드 관련 검색:
4,4'-디페닐메탄 비스-말린이미드 N-클로로숙신이미드 N-아이오도석신이미드 N-브로모숙신산이미드 숙신산이미드 프탈이미드 다이알리포르(디알리포르) N-(벤질옥시카보닐옥시)석신이미드 3-(2-피리딜디티오)프로피온산 N-하이드록시숙신이미드 에스테르 디(N-숙신이미딜)카보네이트 1-[[(9H-플로렌-9-일메톡시)카보닐]옥시]-2,5-필롤리딘디온 N-히드록시석신이미딜 아세토아세트산염 N-히드록시석신이미드
Diethyl succinosuccinate
CHLOROPHOSPHONAZO III
Dispersing agent 155
N-ALLYLPHTHALIMIDE
3-CHLORO-PROPANE-1-SULFONIC ACID TERT-BUTYLAMIDE