클로르족사존
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클로르족사존 속성
- 녹는점
- 191-192 °C (lit.)
- 밀도
- 1.3771 (rough estimate)
- 굴절률
- 1.5557 (estimate)
- 저장 조건
- room temp
- 용해도
- DMSO: 용해성50mg/mL, 투명
- 산도 계수 (pKa)
- pKa 8.3 (Uncertain)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 0.1g/100mL
- Merck
- 14,2194
- LogP
- 1.816 (est)
- CAS 데이터베이스
- 95-25-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22 | ||
안전지침서 | 26-36-24/25-37/39 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DM5250000 | ||
위험 참고 사항 | Toxic/Irritant | ||
TSCA | Yes | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29349990 | ||
독성 | LD50 in mice (mg/kg): 3650 orally, 380 i.p. (suspensions); 440 orally, 183 i.p. (solns of Na salt) (Hofrichter) | ||
기존화학 물질 | KE-05538 |
클로르족사존 C화학적 특성, 용도, 생산
개요
Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Chlorzoxazone, 5-chloro-2-benzoxazolione, is synthesized by a heterocyclization reaction of 2-amino-4-chlorophenol with phosgene. Skeletal muscle relaxants have conventionally been classified into one group; however, they are actually a heterogeneous group of medications commonly used to treat two different types of underlying conditions – spasticity from upper motor neuron syndromes and muscular pain or spasms from peripheral musculoskeletal conditions. Medications classified as skeletal muscle relaxants are baclofen, carisoprodol, chlorzoxazone, cyclobenzaprine, dantrolene, metaxalone, methocarbamol, orphenadrine, and tizanidine. These drugs may impair mental and/or physical abilities required for driving vehicles. As a class, skeletal muscle relaxants have central nervous system (CNS)-related side effects: drowsiness, dizziness, decreased alertness, blurred vision, and ataxia. Their use has been associated with a twofold increase in the risk for motor vehicle crashes. Muscle relaxants are included in the ‘Beers List’ of potentially inappropriate medications in older adults. Most muscle relaxants are poorly tolerated by elderly patients because they cause anticholinergic adverse effects, sedation, and weakness. Although extremely uncommon, this compound may yield to idiosyncratic and unpredictable type of liver toxicity. The concomitant use of alcohol or other CNS depressants may have an additive effect. Individuals on chlorzoxazone containing drugs should be monitored for abnormal liver enzymes (e.g., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, etc.).화학적 성질
White to Off-White Solid용도
Chlorzoxazone is a benzoxazolone derivative that causes skeletal muscle relaxation and blocks spasticity in clinical studies. Chlorzoxazone enhances small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 μM for KCa2.2 and KCa3.1, respectively). The cytochrome P450 isoform CYP2E1 converts chlorzoxazone to 6-hydroxy chlorzoxazone . The urinary excretion of this 6-hydroxy metabolite is often used as a probe of CYP2E1 activity in studies of hepatotoxicity.정의
ChEBI: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful mus le spasm.일반 설명
Chlorzoxazone is a centrally active muscle relaxant used to treat painful muscle spasms linked to musculoskeletal disorders, such as fibrositis, bursitis, myositis, spondylitis, etc.Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
환경귀착
Chlorzoxazone ismetabolized by the CYP1A2 and CYP2E1 microsomal enzymes to a toxic metabolite 6-hydroxychlorzoxazone.클로르족사존 준비 용품 및 원자재
원자재
준비 용품
클로르족사존 공급 업체
글로벌( 389)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Aurora Industry Co., Ltd. | +86-041139802261 +86-13591747876 |
alex1_auco@126.com | China | 276 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Zjartschem | +86-571 87238903 |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
클로르족사존 관련 검색:
세프타졸린 나트륨 에피클로로하이드린 1,2-벤즈아이소티아졸린-3-온 3-메틸-1-페닐-2-피라졸린-5-온 P-클로로아세트페논 트라조돈 클로로디플루오르메탄 클로로아세트산 2(3H)-벤즈옥사졸론 벤나옥사졸
2,4-Dichloro-5-fluoroacetophenone
Nizofenone
6-HYDROXY CHLORZOXAZONE-D2,CHLORZOXAZONE, 6-HYDROXY MAJOR METABOLIT E OF C
Cibenzoline succinate
bromchlorenone
Oxazole
5-CHLOROBENZOXAZOLE
CHLORZOXAZONE-4,6,7-D3