Tauroursodeoxycholic acid

Tauroursodeoxycholic acid 구조식 이미지
카스 번호:
14605-22-2
상품명:
Tauroursodeoxycholic acid
동의어(영문):
TUDCA;Taurolite;ursodeoxycholyltaurine;Tauroursodeoxycholic acid-D4;TUDCA Tauroursodeoxycholic Acid;tauroursodeoxycholic acid sodium;Tauroursodeoxycholic Acid (TUDCA);Tauroursodeoxycholic Acid-[d4] Sodium Salt;3a,7b-Dihydroxy-5b-cholan-24-oic Acid N-(2-Sulfoethyl)amide;ur906
CBNumber:
CB0404332
분자식:
C26H45NO6S
포뮬러 무게:
499.7
MOL 파일:
14605-22-2.mol
MSDS 파일:
SDS

Tauroursodeoxycholic acid 속성

녹는점
173-175°C
밀도
1.216±0.06 g/cm3(Predicted)
굴절률
46 ° (C=1, EtOH)
저장 조건
15-25℃
용해도
DMSO(최대 30mg/ml) 또는 에탄올(가온 시 최대 20mg/ml)에 용해됩니다.
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
1.42±0.50(Predicted)
색상
하얀색
안정성
제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChIKey
BHTRKEVKTKCXOH-LBSADWJPSA-N
SMILES
[C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r|
CAS 데이터베이스
14605-22-2(CAS DataBase Reference)

안전

안전지침서 22-24/25
WGK 독일 2
RTECS 번호 KI7372500
HS 번호 29242990
독성 mouse,LD50,intravenous,350mg/kg (350mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #92-235918,

Tauroursodeoxycholic acid C화학적 특성, 용도, 생산

개요

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.

화학적 성질

Tauroursodeoxycholic acid is an off-White Solid. It is an ambiphilic bile acid. It is mainly found in black bear bile, which is the signature active ingredient in bear bile. It has antispasmodic, anticonvulsant, anti-inflammatory and gallstone dissolving effects.

용도

Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile salt naturally occurring in the body. When bile salts reach the intestines, they can be metabolized by bacteria into ursodeoxycholic acid (UDCA). TUDCA is formed when taurine binds to UDCA. TUDCA is used to treat cholestasis, a condition in which bile fails to flow from the liver to the duodenum. TUDCA, UDCA, and other soluble bile salts can counteract the toxicity of regular bile acids when the latter are backed up in the liver. TUDCA is also used to treat cholesterol gallstones, dissolving them to a size in which they may be passed.

정의

ChEBI: Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursoodeoxycholic acid. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. It derives from an ursodeoxycholic acid. It is a conjugate acid of a tauroursodeoxycholate.

부작용

TUDCA is safe and well-tolerated in patients with liver transplants, liver cirrhosis, and other diseases, but no clinical data exist for treatments longer than 1 year.
There were no significant differences in adverse events between those receiving standard immunosuppressants versus those receiving bile acids in addition. Other trials in liver cirrhosis (up to 6 months) and ALS (1 year) have also reported that TUDCA is well-tolerated with diarrhea being the only side effect (Elia et al., 2016; Ma et al., 2016; Pan et al., 2013; Crosignani et al., 1996).
Tauroursodeoxycholic-Acid-Cognitive-Vitality-For-Researchers

Mode of action

Tauroursodeoxycholic acid is a bile acid taurine conjugate derived from ursodeoxycholic acid. Bile acid is made by the liver and stored in the gallbladder and helps with digestion. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears, which is the signature active ingredient in bear bile. It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.

Tauroursodeoxycholic acid 준비 용품 및 원자재

원자재

준비 용품


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