Pioglitazone hydrochloride
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Pioglitazone hydrochloride 속성
- 녹는점
- 193-194°C
- RTECS 번호
- XJ5813440
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥10mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물(25°C에서 <1mg/ml), DMF, 메탄올, 에탄올(25°C에서 4mg/ml) 및 DMSO(25°C에서 79mg/ml)에 용해됩니다.
- Merck
- 14,7452
- BCS Class
- 2
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- GHUUBYQTCDQWRA-UHFFFAOYSA-N
- CAS 데이터베이스
- 112529-15-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38-36 | ||
| 안전지침서 | 22-24/25-26 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29341000 |
Pioglitazone hydrochloride C화학적 특성, 용도, 생산
개요
Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiourea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insulin resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insulin resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.화학적 성질
Colourless Prisms용도
Pioglitazone hydrochloride is a euglycemic agent,used as an antidiabetic.일반 설명
Pioglitazone hydrochloride is an oral antidiabetic agent used in the treatment of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes.Pioglitazone hydrochloride 준비 용품 및 원자재
원자재
아크릴산메틸
브롬화수소
메틸산 나트륨
COPPER(II) OXIDE
5-Ethyl-2-pyridineethanol
Palladium hydroxide
p-플루오로미트로벤젠
아세트산 나트륨
수소화나트륨
준비 용품
Pioglitazone hydrochloride 공급 업체
글로벌( 675)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12457 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 1175 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Pioglitazone hydrochloride 관련 검색:
2,4-티아졸리딘 디온
Rosiglitazone
Liraglutide
Repaglinide
Melatonine
WY-14643
MK-2206 2HCl
HS-173
Vorinostat
17-AAG
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers)
Hydroxypioglitazone
Pioglitazone Sulfonic Acid IMpurity
2-[2-(4-BroMophenoxy)ethyl]-5-ethylpyridine
a-[(Aminocarbonyl)thio]-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester
4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyaldehyde
Pioglitazone Impurity