6-Dimethylaminopurine
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6-Dimethylaminopurine 속성
- 녹는점
- 259-262 °C(lit.)
- 끓는 점
- 162 °C (50 mmHg)
- 밀도
- 1.1407 (rough estimate)
- 굴절률
- 1.6380 (estimate)
- 인화점
- 110 °C
- 저장 조건
- -20°C
- 용해도
- 메탄올: 0.1 g/mL, 투명
- 물리적 상태
- 세분화된
- 산도 계수 (pKa)
- 9.38±0.20(Predicted)
- 색상
- 황백색에서 노란색까지
- BRN
- 7634
- InChIKey
- BVIAOQMSVZHOJM-UHFFFAOYSA-N
- CAS 데이터베이스
- 938-55-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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유해·위험 문구: |
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6-Dimethylaminopurine C화학적 특성, 용도, 생산
화학적 성질
white to light yellow crystal powder용도
6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. It can be used to rtificially lengthen the pre-maturation period of oocyte growth, in vitro, by inhibiting germinal vesicle breakdown in mouse and human oocytes.주요 응용
6-(Dimethylamino)purine has been used:as a supplement in GR-1 aa medium (bovine medium) for parthenogenetic activation of bovine oocytes to study its potential for embryo development.
in the activation step during the production of nuclear transfer embryos.
as a supplement in HCR2aa medium to activate interspecies embryos derived from interspecies somatic cell nuclear transfer (iSCNT) technique.
A purine antagonist.
In the benzodiazepine receptor (BZR) binding assay, it inhibits the binding of 1.5 nM [3H]diazepam at 100uM in rat brains.
제조 방법
6-Dimethylaminopurine synthesis: 2-Methylmercapto-4-amino-6-dimethylaminopyrimidine (VI) was smoothly nitrosated in 10% acetic acid to the 5-nitrosopyrimidine (V) in 95% yield. Reduction of V with sodium hydrosulfite to the triamine (IV), followed by formylation gave the 5-formamidopyrimidine (VII) in 76% over-all yield for the two steps. Reductive formylation of V directly to VI1 with zinc and formic acid, although more rapid, was less efficient (50% yield). Ring closure of VII to 2-methyhercapto-6-dimethylaminopurine (X) was best done on a small scale by short fusion at 250°(99% yield), although boiling quinoline, formamide, or dilute alcoholic sodium hydroxide could also be employed. The latter reagent was most efficient on a large scale. Desulfurization of X with Raney nickel (7) in 1 N sodium hydroxide at 100° afforded the final product, 6-dimethylaminopurine (XII) in 43% yield.This compound was identical in all respects with the C7H9N5 moiety from puromycin (2).정의
ChEBI: 6-Dimethylaminopurine is a tertiary amine that is adenine substituted at N-6 by geminal methyl groups. It is functionally related to an adenine.일반 설명
6-(Dimethylamino)purine (6-DMAP) is a purine-based metabolite with two condensed heterocyclic rings and two methyl groups linked to the amino group of the purine unit of adenine.Biochem/physiol Actions
6-(Dimethylamino)purine (6-DMAP) is a protein kinase and cyclin-dependent kinase inhibitor. It acts as a secondary metabolite and mediates RNA modification. 6-DMAP is a potent cytokinetic inhibitor and is used in parthenogenesis and meiosis studies. It is also used to promote pronuclei formation in mammalian oocytes. 6-DMAP is a dual fluorescence molecule according to femtosecond fluorescence up-conversion spectroscopy studies.Purification Methods
It is purified by recrystallisation from H2O, EtOH (0.32g in 10mL) or CHCl3. [Albert & Brown J Chem Soc 2060 1954, UV: Mason J Chem Soc 2071 1954.] The monohydrochloride crystallises from EtOH/Et2O, m 2 5 3o(dec) [Elion et al. J Am Chem Soc 74 411 1952], the dihydrochloride has m 225o(dec) and the picrate has m 245o (235-236.5o) [Fryth et al. J Am Chem Soc 80 2736 1958]. [Beilstein 26 III/IV 3566.]6-Dimethylaminopurine 준비 용품 및 원자재
원자재
6-Chloropurine
포스포러스옥시클로라이드
하이포크산틴
N,N-디메틸아닐린
디메틸아민
1H-Imidazole-4-acetonitrile, 5-amino-α-imino-
2'-Deoxy-N6,N6-dimethyladenosine
다이메틸아민 수화염화물
디메틸포름아미드디에틸아세탈
준비 용품
6-Dimethylaminopurine 공급 업체
글로벌( 241)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 |
sales@win-winchemical.com | China | 13854 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Win-Win Chemical CO., Limited | 0086-577-64498589 |
sales@win-winchemical.com | CHINA | 998 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 47465 | 58 |
6-Dimethylaminopurine 관련 검색:
황화디메틸 다이메틸 푸마르산 다이메틸-p-페닐엔디아민 N,N-다이메틸폼아마이드 디메틸 에테르 2,6-루티딘 2, 6-디아미노푸린 에탄 다이메틸 프탈레이트 다이메틸 설폭사이드 퓨린 4-다이메틸아미노피리딘 아데닌
DIMETHYLAMINOPYRIDINE, POLYMER-BOUND
PUROMYCIN DIHYDROCHLORIDE
PUROMYCIN DIHYDROCHLORIDE
6-DIMETHYLAMINOPURINE-9-RIBOSIDE,6-Dimethylaminopurine D-riboside,6-dimethylaminopurine 9-riboside*crystalline
PUROMYCIN AMINONUCLEOSIDE