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U-69593

U-69593 구조식 이미지

카스 번호:: 96744-75-1

상품명:: U-69593

동의어(영문):: U-69593;U-69593 SELECTIVE K OPIOID AG;N-Methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide;N-Methyl-N-[(5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide;Benzeneacetamide, N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-;(5A,7A,8B)-(-)-N-METHYL-(7-(1-PYRROLIDINYL)-1-OXASPIRO (4.5)DEC-8- YL)BENZENEACETAMIDE);U69593, (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide;(5ALPHA,7ALPHA,8BETA)-(+)-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)-BENZENEACETAMIDE;(+)-(5ALPHA,7ALPHA,8BETA)-N-METHYL-N-[7-(1-PYRROLIDINYL)-1-OXASPIRO[4.5]DEC-8-YL]-BENZENEACETAMIDE;Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-

CBNumber:: CB0432261

분자식:: C22H32N2O2

포뮬러 무게:: 356.5

MOL 파일:: 96744-75-1.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 46

U-69593 속성

녹는점: 120-123℃

끓는 점: 518.7±50.0 °C(Predicted)

밀도: 1.13

RTECS 번호: CY1490060

저장 조건: 2-8°C

용해도: H₂O: 14 mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 9.15±0.20(Predicted)

색상: 하얀색

optical activity: [α]/D +7.8°, c = 0.825 in methanol(lit.)

안전

WGK 독일	3

U-69593 C화학적 특성, 용도, 생산

용도

U-69593 is a selective κ-opioid receptor agonist. A safe opioid analgesic.

정의

ChEBI: U69593 is a monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine. It has a role as a kappa-opioid receptor agonist, an anti-inflammatory agent and a diuretic. It is an oxaspiro compound, a N-alkylpyrrolidine, an organic heterobicyclic compound and a monocarboxylic acid amide.

Biological Functions

U-69593 is a single enantiomer with very high selectivity for the kappa receptor in vitro (mu/kappa ratio = 484). It was radiolabelled by a catalytic exchange of tritium for the two aromatic chlorine substituents of the precursor. This ligand is commercially available and has been widely used as a radiolabel for the kappa receptor.
in spinal cordslice preparations from the 9-16-day-old rat,U-69593 produced a na-loxone-reversible depression of spontaneous and electrically evoked activityin dorsal horn neurones.

Biochem/physiol Actions

U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

U-69593 준비 용품 및 원자재

원자재

준비 용품

U-69593 공급 업체

글로벌( 46)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	294	58
Shandong Hanjiang Chemical Co., Ltd	+86-0533-2066820 +8618369939125	hanson@sdhanjiang.com	China	1527	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Chemwill Asia Co.,Ltd.	86-21-51086038	chemwill_asia@126.com	CHINA	23931	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

U-69593 관련 검색:

[3H]U-69593 (1S,2S)-N,N,N''N''-TETRAMETHYL-1,2-CYCLOHEXANEDIAMINE Enadoline U-69,593, [PHENYL-3,4-3H]- (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine CHEMBRDG-BB 4018237 U-69593 trans-4-(Dimethylamino)cyclohexanol (1S,2S)-(+)-N,N-Dimethylcyclohexane-1,2-diamine U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST