1-METHYL-D-TRYPTOPHAN
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1-METHYL-D-TRYPTOPHAN 속성
- 녹는점
- 242-245 °C(lit.)
- 알파
- 12.4o (C = 2 IN ACETIC ACID)
- 끓는 점
- 429.3±35.0 °C(Predicted)
- 밀도
- 1.28
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- DMSO에 용해됩니다(25mg/ml 이상).
- 산도 계수 (pKa)
- 2.26±0.10(Predicted)
- 물리적 상태
- 백색 내지 밝은 갈색의 결정성 분말.
- 색상
- 하얀색
- optical activity
- [α]22/D +12.4°, c = 2 in acetic acid
- 수용성
- Soluble to 5 mM in water with gentle warming
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 최대 1개월 동안 -20°에서 보관할 수 있습니다.
- InChIKey
- ZADWXFSZEAPBJS-SNVBAGLBSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 |
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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1-METHYL-D-TRYPTOPHAN C화학적 특성, 용도, 생산
개요
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.용도
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.1-METHYL-D-TRYPTOPHAN 준비 용품 및 원자재
원자재
준비 용품
1-METHYL-D-TRYPTOPHAN 공급 업체
글로벌( 196)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13349 | 58 |
Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 |
sales@win-winchemical.com | China | 14350 | 58 |
1-METHYL-D-TRYPTOPHAN 관련 검색:
L-아브린
5-METHYL-DL-TRYPTOPHAN
1-METHYL-D-TRYPTOPHAN
1-METHYL-DL-TRYPTOPHAN
Fmoc-D-Trp(Boc)-OH
5-METHYL-DL-TRYPTOPHAN HYDRATE
α-Methyl-(S)-tryptophan,ALPHA-METHYL-L-TRYPTOPHAN
1-METHYL-L-TRYPTOPHAN
D(+)-Tryptophan
BOC-D-TPI(FOR)-OH
Z-D-TRP(BOC)-OH
FMOC-D-TRP(ME)-OH
H-D-TRP(BOC)-OH
7-METHOXY-1-METHYL-D-TRYPTOPHAN ETHYL ESTER
BOC-D-TRP(FOR)-OH
H-D-TRP(FOR)-OH HCL
BOC-N-ALPHA-METHYL-DL-TRYPTOPHAN
4-METHYL-DL-TRYPTOPHAN