SWAINSONINE
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SWAINSONINE 속성
- 녹는점
- 148-149°C
- 끓는 점
- 353.3±21.0 °C(Predicted)
- 밀도
- 1.38±0.1 g/cm3 (20 ºC 760 Torr)
- 저장 조건
- -20°C
- 용해도
- H2O: 용해성1mg/mL
- 산도 계수 (pKa)
- 14.01±0.60(Predicted)
- 물리적 상태
- 동결건조된 분말
- 색상
- 흰색에서 희미한 노란색까지
- 수용성
- 물에 50mM까지 용해됨
- BRN
- 4175740
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO, 에탄올 또는 증류수에 용해된 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 72741-87-8
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
SWAINSONINE C화학적 특성, 용도, 생산
화학적 성질
White Crystalline Solid출처
Swainsonia canescens yields this simple alkaloid.용도
Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydrolysis of mannosidases. Swainsonine completely inhibits mammalian Golgi a-mannosidase II (a-3/6-mannosidase in the glycoprotein processing pathway) and mammalian lysosomal a-mannosidase (acid mannosidase). At higher concentrations, swainsonine also inhibits mammalian cytosolic a-mannosidase. It has been shown to inhibit growth of transformed fibroblasts in soft agar and to enhance the antiproliferative effects of INF on murine lymphoreticular tumor cells in vitro. It also blocks the expression of b1-6 branched complex-type oligosaccharides and shunts the pathway towards hybrid-type oligosaccharides. Swainsonine does not appear to inhibit secretion or expression of glycoproteins at the cell surface. Swainsonine is stable for at least 24 h at 37oC in culture media at physiological pH. Working concentration range is 17-1700 ng/ml (0.1-10mM). Swainsonine (at 1 mg/ml) is not cytotoxic and does not inhibit the growth of a variety of mammalian cell lines. Concentrations required to inhibit Golgi a-mannosidase II in vivo may be somewhat higher, as swainsonine tends to concentrate in the acid environment of cell lysosomes, where it exists as a charged cation and does not permeate through membranes readily. Swainsonine blocks the processing of high-mannose oligosaccharides to complex oligosaccharides. Glycoproteins synthesized in the presence of swainsonine tend to carry mostly high-mannose and hybrid oligosaccharide chains. With short treatments (<24 h) with the inhibitor, cells may retain some complex glycoproteins due to asynchronous cell growth and glycoprotein synthesis.정의
ChEBI: An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.일반 설명
Swainsonine is produced by endophytes, plant and insect pathogens. It is synthesized from the pipecolic acid and mevalonic acid. Swainsonine is a water-soluble indole alkaloid.생물학적 활성
Inhibitor of α -mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.SWAINSONINE 준비 용품 및 원자재
원자재
준비 용품
SWAINSONINE 공급 업체
글로벌( 163)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2935 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
Shandong Zhishang New Material Co., Ltd. | +8617653113209 |
sales002@sdzschem.com | China | 3050 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
SWAINSONINE 관련 검색:
1-카복시-N,N,N-트라이메틸메탄아미늄, 분자내염
CONDURITOL B EPOXIDE
(-)-Gossypol
Mitomycin C
C2 CERAMIDE
1-Hexanol
1-Octacosanol
SWAINSONINE(P)
1,2-di-epi-swainsonine
swainsonine N-oxide
L-(+)-SWAINSONINE
1,2-ISOPROPYLIDENE SWAINSONINE
SWAINSONINE-6,7-3H
6,7-DIHYDROXYSWAINSONINE
SWAINSONINE
(1S,2R,8R,8AR)-1,2,8-TRIACETOXY-OCTAHYDRO-5-OXYINDOLIZINE