4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 속성
- 녹는점
- 162-164?C
- 끓는 점
- 475.8±55.0 °C(Predicted)
- 밀도
- 1.357±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 9.53±0.60(Predicted)
- 색상
- 흰색에서 황백색까지
- BRN
- 5438165
- InChIKey
- ZXPCUGWAKUIOOF-UHFFFAOYSA-N
- CAS 데이터베이스
- 72811-73-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide C화학적 특성, 용도, 생산
화학적 성질
White to Off-White Solid용도
Torasemide intermediate.Synthesis
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 준비 용품 및 원자재
원자재
4-Amino-3-pyridinesulfonamide
4-Chloro-3-pyridinesulfonamide hydrochloride,98%
4-Chloro-3-pyridinesulfonamide
m-아이오도툴루엔
m-톨루이딘
준비 용품
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 공급 업체
글로벌( 308)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 8349 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 관련 검색:
설파마이드
Torasemide Impurity
4-CHLORO-3-PYRIDINESULFONIC ACID
2-Pyridinesulfonamide,4-chloro-(9CI)
4-Hydroxypyridine-3-sulfonic acid
4-Chloro-3-Pyridine-sulfonyl-chloride
Torsemide Related Compound 1
[[4-[(3-Methylphenyl)aMino]-3-pyridinyl]sulfonyl]carbaMic Acid Ethyl Ester
Torsemide Impurity E
1-Ethyl-3-[[4-(m-toluidino)-3-pyridyl]sulfonyl]urea
N-[(n-butylaMino)carbonyl]-4-[(3-Methylphenyl)aMino]-3-pyridinesulfonaMide
Torasemide
4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide
N-[[(1-Methylethyl-d7)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
3-Pyridinesulfonamide
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
Galosemide
TORSEMIDE RELATED COMPOUND A (75 MG) (4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE)