즉시 의료기관(의사)의 진찰을 받으시오.
삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P320
긴급히 (…) 처치를 하시오.
P321
(…) 처치를 하시오.
P322
특정 조치(라벨의 … 참조)
P330
입을 씻어내시오.
P361
즉시 오염된 의복을 모두 벗을 것
P363
다시 사용전 오염된 의류는 세척하시오.
P403+P233
용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
4
0
TETRODOTOXIN C화학적 특성, 용도, 생산
개요
Tetrodotoxin (TTX) is a selective sodium channel blocker
nonprotein heat-stable toxin. The mechanism of toxicity is
through the blockage of fast voltage-gated sodium channels.
The consumption of toxic amounts of TTX results primarily in
neurologic and gastrointestinal signs and symptoms. TTX is
widely distributed in marine taxa such as pufferfish and
porcupine fish (suborders of the Tetraodontiformes order),
salamanders of the family Salamandridae, Central American
frogs (genus Atelopus), shellfish, starfish, crabs, and some
species of ribbonworm and octopus. However, in terrestrial
taxa, it is limited to a single class of vertebrates (Amphibia).
TTX is now known to be produced not by puffer but by
bacteria, and reaches various species of animals via food chain.
화학적 성질
white powder
용도
Tetrodotoxin is a highly selective, reversible sodium channel blocker.
정의
ChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
생물학적 활성
Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. When heated to
decomposition it emits toxic fumes of Nox.
