BAY 11-7085
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BAY 11-7085 속성
- 녹는점
- 80-82℃
- 끓는 점
- 407.1±45.0 °C(Predicted)
- 밀도
- 1.144
- 인화점
- 200℃
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO: >25mg/mL, 용해성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 감도
- Light Sensitive
- InChIKey
- VHKZGNPOHPFPER-ONNFQVAWSA-N
- CAS 데이터베이스
- 196309-76-9
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| RTECS 번호 | UD1312500 | ||
| HS 번호 | 29309090 |
BAY 11-7085 C화학적 특성, 용도, 생산
용도
Bay 11-7085 has been used as:- nuclear factor-κB inhibitor in Panc-1 cells, macrophages
- inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
- phospho-p65 inhibitor human monocyte cell line THP-1
생물학적 활성
Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .Biochem/physiol Actions
Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit αBAY 11-7085 준비 용품 및 원자재
원자재
준비 용품
BAY 11-7085 공급 업체
글로벌( 106)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | |
sales@boylechem.com | China | 2923 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
BAY 11-7085 관련 검색:
HELENALIN
5-Aminosalicylic acid
LY2228820
QNZ (EVP4593)
Saracatinib
Belinostat (PXD101)
BI 2536
Lenvatinib
(2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid
Pracinostat
ML264
WITHAFERIN A
ROCAGLAMIDE
3'-Hydroxyrocaglamide
panepoxydone
Rocaglamide I
BAY 11-7082
BAY 11-7085