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5-Methoxytryptamine

5-Methoxytryptamine 구조식 이미지
카스 번호:
608-07-1
상품명:
5-Methoxytryptamine
동의어(영문):
5MOT;MEXAMINE;608-07-1;Meksamin;EOS-62441;NSC 56422;AKOS B028531;AKOS BB-5620;Mexamine base;AURORA KA-7772
CBNumber:
CB0676885
분자식:
C11H14N2O
포뮬러 무게:
190.24
MOL 파일:
608-07-1.mol

5-Methoxytryptamine 속성

녹는점
121-123 °C (lit.)
끓는 점
325.75°C (rough estimate)
밀도
1.0815 (rough estimate)
굴절률
1.5700 (estimate)
저장 조건
2-8°C
산도 계수 (pKa)
16.91±0.30(Predicted)
물리적 상태
crystalline
색상
white
Merck
13,6032
BRN
145587
InChIKey
JTEJPPKMYBDEMY-UHFFFAOYSA-N
CAS 데이터베이스
608-07-1(CAS DataBase Reference)
NIST
5-Methoxytryptamine(608-07-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-36/37/38-20/21/22
안전지침서 36-26
WGK 독일 3
RTECS 번호 NL4110000
F 고인화성물질 8
HS 번호 29339900
독성 LD50 intraperitoneal in mouse: 176mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

5-Methoxytryptamine MSDS


5-Methoxytryptamine

5-Methoxytryptamine C화학적 특성, 용도, 생산

개요

5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.

화학적 성질

White to tan crystalline powder

용도

A tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.

용도

5HT agonist

용도

5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.
Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
Melatonin analogs for the reduction of intraocular pressure
5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Aurora and epidermal growth factor receptor kinase inhibitors
Agents for the treatment of human papillomavirus infection
Manzamine analogues for the control of neuroinflammation and cerebral infections
Inhibitors of pro-inflammatory cytokines
Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease

정의

ChEBI: 5-methoxytryptamine is a member of the class of tryptamines that is the methyl ether derivative of serotonin. It has a role as a serotonergic agonist, a human metabolite, a mouse metabolite, a 5-hydroxytryptamine 2A receptor agonist, a 5-hydroxytryptamine 2C receptor agonist, a 5-hydroxytryptamine 2B receptor agonist, an antioxidant, a radiation protective agent, a neuroprotective agent and a cardioprotective agent. It is a member of tryptamines, an aromatic ether and a primary amino compound. It derives from a serotonin. It is a conjugate base of a 5-methoxytryptamine(1+).

일반 설명

The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.

Biochem/physiol Actions

Nonselective serotonin receptor agonist that lacks affinity for the 5-HT3 receptor.

Chemical Synthesis

5-Methoxytryptamine (358) was synthesized from 3-(2-iodoethyl)-5-methoxyindole (176) by reaction with 1-methyl-benzylamine (MeCN, 24 h, RT) and subsequent catalytic debenzylation of 44 (H2, Pd/C, EtOH, 24 h, RT, 4 bar). The resulting 5-methoxytryptamine (358 was then reacted with 4-bromobenzoylchloride (THF, NEt3, RT, ON) and the resulting tryptamide 359 was reduced with aluminum hydride to N-(4-bromobenzyl)-5-methoxytryptamine (19) (LiAlH4, AlCl3, Et2O, 5 h, RT), which was isolated as its hydrogen oxalate salt.
synthesis of 5-Methoxytryptamine

Clinical claims and research

The effects of the 5-HT receptor agonist, 5-methoxytryptamine, on plasma glucose levels were investigated in rats. 5-Methoxytryptamine induced a significant hyperglycemia above the dosage of 1 mg/kg. 5-Methoxytryptamine-induced hyperglycemia was antagonized by pretreatment with the 5-HT1 and 5-HT2 receptor antagonist, methysergide, or the 5-HT2A receptor antagonist, ketanserin, whereas the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, and the 5-HT4 receptor antagonist, SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester), showed no effect. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, reduced 5-methoxytryptamine-induced hyperglycemia.
Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.

5-Methoxytryptamine 준비 용품 및 원자재

원자재

준비 용품


5-Methoxytryptamine 공급 업체

글로벌( 342)공급 업체
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+86-571-56059825 fandachem@gmail.com CHINA 9150 55
Rixing Chemical CO.,LTD
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ATK CHEMICAL COMPANY LIMITED
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Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55

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