Curcumol

Curcumol 구조식 이미지
카스 번호:
4871-97-0
상품명:
Curcumol
동의어(영문):
Curcumo;CURCUMOL;Curcumae;(-)-Curcumol;Curcumol USP/EP/BP;5,8-Epoxy-10(14)-guaien-8-ol;(3S,3aS,5S,6R,8aS)-5-Isopropyl-3-methyl-8-methyleneoctahydro-6H-3a,6-epoxyazulen-6-ol;(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol;6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,3aS,5S,6R,8aS)-;(3s-(3a,3aa,5a,6a,8ab))-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6h-3a,6-epoxyazulen-6-ol
CBNumber:
CB0701727
분자식:
C15H24O2
포뮬러 무게:
236.35
MOL 파일:
4871-97-0.mol
MSDS 파일:
SDS

Curcumol 속성

녹는점
141.0 to 145.0 °C
끓는 점
334.5±42.0 °C(Predicted)
밀도
1.06±0.1 g/cm3(Predicted)
저장 조건
under inert gas (nitrogen or Argon) at 2–8 °C
용해도
DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM)
Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM)
산도 계수 (pKa)
13.02±0.60(Predicted)
물리적 상태
Solid
색상
흰색에서 밝은 노란색
InChI
InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
InChIKey
QRMPRVXWPCLVNI-YYFQZIEXSA-N
SMILES
C1[C@]2([H])[C@@]3(O[C@](O)(CC2=C)[C@H](C(C)C)C3)[C@@H](C)C1
LogP
3.276 (est)
CAS 데이터베이스
4871-97-0

안전

WGK 독일 3
HS 번호 29321900

Curcumol C화학적 특성, 용도, 생산

Pharmacokinetics

Curcumol is rapidly absorbed and eliminated in rats following oral administration of 10, 40 and 80 mg/kg curcumol. Its oral and intravenous bioavailability ranges from 9.2% ~ 13.1%. Maximum concentration is reached within 0.5-1.0 hours. In addition, high protein binding of curcumin was observed in rat plasma, ranging from 85.6% to 93.4%.

참고 문헌

[1] Wei Wei. “Curcumol: From Plant Roots to Cancer Roots.” International Journal of Biological Sciences 27 1 (2019): 1600–1609.
[2] Ying Liu. “Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling.” Cell Death Discovery 10 1 (2024): 300.

Curcumol 준비 용품 및 원자재

원자재

준비 용품


Curcumol 공급 업체

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