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염화벤잘코늄

염화벤잘코늄
염화벤잘코늄 구조식 이미지
카스 번호:
8001-54-5
한글명:
염화벤잘코늄
동의어(한글):
네오-저미톨;디만닌;비오놀;오스반;제피란클로라이드ALKYL-BENZYL-DIMETHYLAMMONIUMCHLORIDE;콰트라민;록칼-D(R);알킬디메틸벤질암모늄클로라이드;염화알킬디메틸벤질암모늄;염화벤잘코늄;벤잘코늄클로라이드;벤잘코늄 클로라이드 (방부제);4차 알킬벤질다이메틸암모늄 염화물;N-알킬 다이메틸 벤질 암모늄 염화물;염화 4차 알킬다이메틸(페닐메틸)암모늄;염화 벤잘코늄;염화 알킬다이메틸벤질암모늄;염화 알킬벤질다이메틸암모늄;제피란 클로라이드;제피란클로라이드
상품명:
Benzalkonium chloride
동의어(영문):
BAK;BAC;BKC;Osvan;Welpas;DIMANIN;ZEPHARIN;ZEPHIRAN;264-151-6;Parasterol
CBNumber:
CB0712969
분자식:
C17H30ClN
포뮬러 무게:
283.88
MOL 파일:
8001-54-5.mol

염화벤잘코늄 속성

끓는 점
>100°C/760mmHg
밀도
0.98
저장 조건
2-8°C
용해도
Very soluble in water and in ethanol (96 per cent). An aqueous solution froths copiously when shaken.
물리적 상태
Viscous Solution
색상
Clear or white to yellow, may contain yellow-white fragments
Specific Gravity
0.98
안정성
Stable. Incompatible with strong oxidizing agents, moisture. Hygroscopic.
CAS 데이터베이스
8001-54-5(CAS DataBase Reference)
EPA
Benzalkonium chloride (8001-54-5)

안전

위험품 표기 C,N
위험 카페고리 넘버 21/22-34-50
안전지침서 36/37/39-45-61
유엔번호(UN No.) UN 3261 8/PG 3
WGK 독일 3
RTECS 번호 BO3151000
F 고인화성물질 3-9
HS 번호 34021200
유해 물질 데이터 8001-54-5(Hazardous Substances Data)
독성 LD50 orally in rats: 400 mg/kg (Cummins, Kimura)
기존화학 물질 KE-00790
유해화학물질 필터링 97-1-200
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 염화 N-알킬디메틸벤질암모늄 및 이를 1% 이상 함유한 혼합물

염화벤잘코늄 MSDS


Alkyldimethylbenzylammonium chloride

염화벤잘코늄 C화학적 특성, 용도, 생산

개요

Benzalkonium chloride is a quaternary ammonium mixture of alkyl, dimethyl and benzyl ammonium chlorides.It is an irritant rather than a sensitizer, but may cause contact dermatitis in nursing and medical personnel. An unusual case was reported in a farm worker who used a detergent containing benzalkonium chloride to clean the piggery.

화학적 성질

Benzalkonium chloride occurs as a white or yellowish-white amorphous powder, a thick gel, or gelatinous flakes. It is hygroscopic, soapy to the touch, and has a mild aromatic odor and very bitter taste.

화학적 성질

white or light yellow/grey solid, or colourless aqueous solution

용도

antiarthritic, cyclooxygenase2 inhibitor

용도

benzalkonium chloride is a preservative with anti-microbial and deodorant properties. It can also be used as a surfactant. With continuous use, it may cause occasional allergic reactions.

용도

Cationic surface active agent and germicide. Pharmaceutic aid (preservative). Algicide.

정의

ChEBI: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.

생산 방법

Benzalkonium chloride is formed by the reaction of a solution of Nalkyl- N-methylbenzamine with methyl chloride in an organic solvent suitable for precipitating the quaternary compound as it is formed.

상표명

Roccal (Sterling Winthrop); Zephiran Chloride (Sterling Winthrop).

위험도

Highly toxic; poison.

농업용

Biocide, Algaecide, Fungicide: Used as an algaecide to control slime mold, algae, fish pathogens, and mollusks in ponds, canals and bodies of water. Also widely used in deodorants, detergents, sanitizers and germicides for applications in food plants, laundries, and operating rooms. Not listed for use in EU countries . Registered for use in the U.S. but not California.

Pharmaceutical Applications

Benzalkonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative in applications similar to other cationic surfactants, such as cetrimide. In ophthalmic preparations, benzalkonium chloride is one of the most widely used preservatives,at a concentration of 0.01–0.02% w/v. Often it is used in combination with other preservatives or excipients, particularly 0.1% w/v disodium edetate, to enhance its antimicrobial activity against strains of Pseudomonas.
In nasal, and otic formulations a concentration of 0.002–0.02% w/v is used, sometimes in combination with 0.002–0.005% w/v thimerosal. Benzalkonium chloride 0.01% w/v is also employed as a preservative in small-volume parenteral products. Benzalkonium chloride was also shown to enhance the topical penetration of lorazepam.
Benzalkonium chloride is additionally used as a preservative in cosmetics.

상품명

AMMONYX®; ARQUAD DMMCB-75®; BARQUAT® MB-50; BARQUAT® MB-80; BAYCLEAN®; BIO-QUAT 50-24®; CATAMINE® AB; CONSAN®; DRAPOLENE®; GARDIQUAT®-1450; HYAMINE®-3500; INTEXAN® LB-50; KATAMINE® AB; NEO GERM-I-TOL®; ONYX BTC; OSVAN; RODALON®; SENTINEL®; TRITON® K-60; VIKROL® RQ

색상 색인 번호

This quaternary ammonium cationic surfactant is a mixture of alkyl, dimethyl, and benzyl ammonium chlorides (-R). It is an irritant rather than a sensitizer, but may cause allergic contact dermatitis from creams, detergents/antiseptics, ophthalmic preparations, and in nursing, veterinary, dental, and medical personnel. Its presence was observed in plaster of Paris.

Clinical Use

Alkylbenzyldimethylammonium chloride (Zephiran) is a mixtureof alkylbenzyldimethylammonium chlorides of the generalformula [C6H5CH2N(CH3)2R] Cl , where R represents amixture of alkyl chains beginning with C8H17 and extendingto higher homologues with C12H25, C14H29, and C16H33. The higher–molecular-weight homologues compose the majorfractions. Although variations in the physical and antimicrobialproperties exist between individual members of the mixture,they are of little importance in the chemistry of the overallproduct. Benzalkonium chloride occurs as a white gel thatis soluble in water, alcohol, and organic solvents. Aqueous solutionsare colorless, slightly alkaline, and very foamy.
Benzalkonium chloride is a detergent, an emulsifier, anda wetting agent. It is used as an antiseptic for skin and mucousmembranes in concentrations of 1:750 to 1:20,000. Forirrigation, 1:20,000 to 1:40,000 concentrations are used. Forstorage of surgical instruments, 1:750 to 1:5,000 concentrationsare used, with 0.5% NaNO3 added as a preservative.

Safety

is well tolerated in the dilutions normally employed on the skin and mucous membranes. However, benzalkonium chloride has been associated with adverse effects when used in some pharmaceutical formulations.
Ototoxicity can occur when benzalkonium chloride is applied to the ear and prolonged contact with the skin can occasionally cause irritation and hypersensitivity. Benzalkonium chloride is also known to cause bronchoconstriction in some asthmatics when used in nebulizer solutions.
Toxicity experiments with rabbits have shown benzalkonium chloride to be harmful to the eye in concentrations higher than that normally used as a preservative. However, the human eye appears to be less affected than the rabbit eye and many ophthalmic products have been formulated with benzalkonium chloride 0.01% w/v as the preservative.
Benzalkonium chloride is not suitable for use as a preservative in solutions used for storing and washing hydrophilic soft contact lenses, as the benzalkonium chloride can bind to the lenses and may later produce ocular toxicity when the lenses are worn. Solutions stronger than 0.03% w/v concentration entering the eye require prompt medical attention.
Local irritation of the throat, esophagus, stomach, and intestine can occur following contact with strong solutions (>0.1% w/v). The fatal oral dose of benzalkonium chloride in humans is estimated to be 1–3 g. Adverse effects following oral ingestion include vomiting, collapse, and coma. Toxic doses lead to paralysis of the respiratory muscles, dyspnea, and cyanosis.
LD50 (mouse, oral): 150 mg/kg
LD50 (rat, IP): 14.5 mg/kg
LD50 (rat, IV): 13.9 mg/kg
LD50 (rat, oral): 300 mg/kg
LD50 (rat, skin): 1.42 g/kg

저장

Benzalkonium chloride is hygroscopic and may be affected by light, air, and metals.
Solutions are stable over a wide pH and temperature range and may be sterilized by autoclaving without loss of effectiveness. Solutions may be stored for prolonged periods at room temperature. Dilute solutions stored in polyvinyl chloride or polyurethane foam containers may lose antimicrobial activity.
The bulk material should be stored in an airtight container, protected from light and contact with metals, in a cool, dry place.

비 호환성

Incompatible with aluminum, anionic surfactants, citrates, cotton, fluorescein, hydrogen peroxide, hypromellose,iodides, kaolin, lanolin, nitrates, nonionic surfactants in high concentration, permanganates, protein, salicylates, silver salts, soaps, sulfonamides, tartrates, zinc oxide, zinc sulfate, some rubber mixes, and some plastic mixes.
Benzalkonium chloride has been shown to be adsorbed to various filtering membranes, especially those that are hydrophobic or anionic.

Regulatory Status

Included in the FDA Inactive Ingredients Database (inhalations, IM injections, nasal, ophthalmic, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. It is also included in the Canadian List of Acceptable Non-medicinal Ingredients.

염화벤잘코늄 준비 용품 및 원자재

원자재

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