터트-부틸시아노아세트산
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터트-부틸시아노아세트산 속성
- 끓는 점
- 40-42 °C/0.1 mmHg (lit.)
- 밀도
- 0.988 g/mL at 20 °C (lit.)
- 굴절률
- n
20/D 1.420
- 인화점
- 91°C
- 저장 조건
- 2-8°C
- 용해도
- 혼합하기가 어렵습니다.
- 산도 계수 (pKa)
- 3.21±0.10(Predicted)
- 물리적 상태
- 기름
- 색상
- 무색의
- BRN
- 1755933
- InChI
- InChI=1S/C7H11NO2/c1-7(2,3)10-6(9)4-5-8/h4H2,1-3H3
- InChIKey
- BFNYNEMRWHFIMR-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CC#N
- CAS 데이터베이스
- 1116-98-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
터트-부틸시아노아세트산 C화학적 특성, 용도, 생산
화학적 성질
Yellow liquid용도
tert-Butyl cyanoacetate is used in the synthesis of vinylogous urea and tert-butyl phenylcyanoacrylates. It is also used as a new additive for the sugar nucleoside base coupling step en route to DAPD with improved β-selectivity.일반 설명
tert-Butyl cyanoacetate undergoes functionalization and decarboxylation to form 3-amino-4-alkyl isoquinolines.Synthesis
tert-butyl cyanoacetate synthesis: 2-Cyanoacetic acid (1.701 g, 20 mmol) was suspended in a cetonitrile (20 ml) and tert-butanol (2.391 ml, 25.00 mmol). To this, a solution of N,N′-Dicyclohexylcarbodiimide (4.54 g, 22.00 mmol) in DCM (22 ml) was added under stirring at RT. The reaction mixture was stirred for 30 minutes, then filtered through Celite, and the solvents were evaporated. Proton NMR analysis of the residue showed complete conversion to the product. The product, tert-butyl cyanoacetate was not purified, but was taken straight through to the next reaction.
1H NMR (400 MHz, CDCl 3 ) δ 3.37 (s, 2H), 1.50 (s, 9H).
Purification Methods
The IR spectrum of a film should have bands at 1742 (ester CO) and 2273 (CN), but no band at ca 3500 broad (OH) cm-1 . If it does not have the last-named band, then fractionally distil; otherwise dissolve in Et2O, wash with saturated aqueous NaHCO3, dry over K2CO3, evaporate Et2O, and distil the residue under a vacuum (see tert-butyl ethyl malonate for precautions to avoid decomposition during distillation). [Beech & Piggott J Chem Soc 423 1955, Dahn & Hauth Helv Chim Acta 42 1214 1959, Beilstein 2 I 255.]터트-부틸시아노아세트산 준비 용품 및 원자재
원자재
클로로아세트산터셔리부틸에스테르
사이안화 칼륨
TETRAETHYLAMMONIUM CYANIDE
시안초산
Acetyl chloride, cyano-
tert-부틸알코올
터트-부틸브로모아세드산
이소부텐
준비 용품
터트-부틸시아노아세트산 공급 업체
글로벌( 299)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Jiangsu Guiren Medicine Co.,Ltd | +86-13815020719 +86-13815020719 |
guiren_medicine@163.com | China | 93 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
터트-부틸시아노아세트산 관련 검색:
시안초산 터트-부틸시아노아세트산
tert-Butyl methyl ether
tert-Butyl acetoacetate
Ethyl cyanoacetate
Ethyl N-cyanoethanimideate
Isobutyl cyanoacetate
Ethyl cyanoformate
Sodium cyanoborohydride
Vitamin B12
BENZYL CYANOACETATE
Cyanomethanesulfonyl chloride
Diethyl cyanomethylphosphonate
2-Octyl cyanoacetate
N-Carbethoxy-4-piperidone
tert-Butyl chloroacetate
tert-Butyl bromoacetate
tert-Butyl carbazate