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에피카테킨 갈레이트

에피카테킨 갈레이트
에피카테킨 갈레이트 구조식 이미지
카스 번호:
1257-08-5
한글명:
에피카테킨 갈레이트
동의어(한글):
에피카테킨 갈레이트
상품명:
(-)-Epicatechin gallate
동의어(영문):
L-ECG;(-)-ECG;Nsc636594;Teatannin;Aids000675;Aids-000675;ECG)()-Epicatechin;epicatechol,gallate;3-O-Galloylgatechin;Cathechin 3-gallate
CBNumber:
CB0738543
분자식:
C22H18O10
포뮬러 무게:
442.37
MOL 파일:
1257-08-5.mol

에피카테킨 갈레이트 속성

녹는점
257-258°C
알파
-182~-194°(D/20℃)(c=0.2,CH3OH)
끓는 점
861.7±65.0 °C(Predicted)
밀도
1.80±0.1 g/cm3(Predicted)
저장 조건
2-8°C
산도 계수 (pKa)
7.75±0.25(Predicted)
수용성
Soluble in water, acetone, DMSO, methanol.
InChIKey
LSHVYAFMTMFKBA-TZIWHRDSSA-N
CAS 데이터베이스
1257-08-5(CAS DataBase Reference)

안전

안전지침서 24/25
WGK 독일 3
RTECS 번호 DH9030000
F 고인화성물질 10-23
HS 번호 29329990

에피카테킨 갈레이트 C화학적 특성, 용도, 생산

화학적 성질

White powder

용도

One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the c atechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.

용도

An antioxidant investigated as an adjunct treatment of some methyicillin resistant bacteria.

용도

(-)-Epicatechin gallate is polyphenols which are abundant in green and black teas. (-)-Epicatechin gallate (ECG) is a natural catechin with a single galloyl group. The hydroxyl groups of ECG contribute to its potent antioxidant activity and facilitate the killing of methicillin-resistant strains of S. aureus.

정의

ChEBI: A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.

일반 설명

(?)-Epicatechin gallate is one of the major polyphenols present in green tea. It belongs to the catechin gallates group of organic compounds. ECG has a chemical structure like that of (?)-epigallocatechin gallate (EGCG), the other major polyphenol found in green tea.

Biochem/physiol Actions

(?)-Epicatechin gallate (ECG), a potent free-radical scavenger has an inhibitory effect on collagenase and elastase enzymes making it an anti-aging agent. It displays antiproliferative effects on human colorectal cells and hence is a chemo-preventative agent. It influences cell survival, preventing apoptosis or autophagy by promoting cell proliferation in oxygen-glucose deprived human brain microvascular endothelial cells. Being structurally and functionally similar to EGCG, ECG might be involved in balancing the mammalian target of rapamycin (mTOR)-AMP-activated protein kinase (AMPK) pathways in endoplasmic reticulum stress. It prevents cell death in this scenario by showing resistance against oxygen-deprived cells. ECG may contribute in preventing oxidative stress. It effectively inhibits secretory sphingomyelinase in many disease states and provides protection for human spermatozoa in Assisted reproductive technology (ART).

에피카테킨 갈레이트 준비 용품 및 원자재

원자재

준비 용품


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