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PHORBOL

PHORBOL 구조식 이미지

카스 번호:: 17673-25-5

상품명:: PHORBOL

동의어(영문):: PHORBOL;Phorbol >99%;Phorbol, >96%;4-beta-phorbol;phorbol white powder;phorbol practical grade;6,8-alpha-tetramethyl-l)-1;in stock Phorbol 17673-25-5;4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-et;4,9,12-beta,13,20-pentahydroxy-1,6-tigliadien-3-on

CBNumber:: CB0741431

분자식:: C20H28O6

포뮬러 무게:: 364.43

MOL 파일:: 17673-25-5.mol

속성

안전

용도

공급 업체 100

PHORBOL 속성

녹는점: 162-163° and 233-234°; mp 249-250°

알파: D24 +102° (water); D20 +118° (c = 0.4 in dioxane)

끓는 점: 415.62°C (rough estimate)

밀도: 1.4

굴절률: 1.4450 (estimate)

저장 조건: Sealed in dry,Store in freezer, under -20°C

수용성: 물에 용해됨

용해도: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: slightly soluble; PBS (pH 7.2): 1 mg/ml

물리적 상태: powder to crystal

산도 계수 (pKa): 11.36±0.70(Predicted)

색상: White to Orange to Green

InChIKey: QGVLYPPODPLXMB-UBTYZVCOSA-N

SMILES: C1(=O)[C@]2(O)[C@]([H])([C@@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)C(C)(C)[C@@]4([H])[C@]3([H])C=C(CO)C2)C=C1C

CAS 데이터베이스: 17673-25-5

EPA: Phorbol (17673-25-5)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T+
위험 카페고리 넘버	26/27/28-36/37/38
안전지침서	26-27-36/37/39-45-28
유엔번호(UN No.)	UN 2811 6.1/PG 3
WGK 독일	3
RTECS 번호	GZ0600000
위험 등급	6.1(b)
포장분류	III
HS 번호	29062990
유해 물질 데이터	17673-25-5(Hazardous Substances Data)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고		P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	0
4		0

PHORBOL C화학적 특성, 용도, 생산

개요

Phorbol is a diterpene originally isolated from croton oil. It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.

용도

Phorbol is a plant-derived diterpene that exhibits various biological activities such as its role as tumor promoters through the activation of protein kinase C.

제조 방법

Phorbol can be extracted from croton oil by two-phase alcoholysis and purified by high-speed counter-current chromatography^[1]. The specific method is as follows:
The optimized operation conditions of biphasic alcoholysis were a reaction time of 91 min, a temperature of 14°C, and a croton oil-methanol ratio of 1:30 (g:ml). The phorbol during the biphasic alcoholysis was 3.2-fold higher in content than that obtained in conventional monophasic alcoholysis. The optimized high-speed countercurrent chromatography method was using the ethyl acetate/n-butyl alcohol/water at 4.7:0.3:5 (v:v:v) with Na2SO4 at 0.36 g/10 ml as the solvent system, using the mobile phase flow rate of 2 ml/min, the revolution of 800 r/min, under which the retention of the stationary phase was achieved at 72.83%. The crystallized phorbol following high-speed countercurrent chromatography was obtained as high purity of 94%.

정의

ChEBI: A diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions.

일반 설명

White solid.

공기와 물의 반응

Water soluble.

반응 프로필

PHORBOL is unstable to prolonged exposure to air, light and ambient temperatures. PHORBOL is also sensitive to acid and alkalis and is subject to autooxidation. PHORBOL dissolves slowly, therefore solution in a desired solvent is best accomplished by prolonged shaking under an inert atmosphere. .

화재위험

PHORBOL is probably combustible.

PHORBOL 준비 용품 및 원자재

원자재

메토트렉세이트

준비 용품

Bisdecanoic acid (1aR)-1aα,1bβ,4,4a,5,7aα,7b,8,9,9a-decahydro-3-(decanoyloxy)methyl-4aβ,7bα-dihydroxy-1,1,6,8α-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulene-9β,9aα-diyl ester

PHORBOL 공급 업체

글로벌( 100)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hpets Biotech Company (Chongqing) Co.,ltd	+8613340353813	info@hanpets.com	China	26	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58

PHORBOL 관련 검색:

PHORBOL PHORBOL (12-MYRISTOYL-13-ACETYL),PHORBOL 12-MYRISTATE 13-ACETATE,phorbol12-tetradecanoate13-acetat phorbol10,11-diacetat PHORBOL-12-BUTYRATE PHORBOL 12,13-DIBUTYRATE PHORBOL 12,13-DIDECANOATE PHORBOL 12-MYRISTATE-13-ACETATE-4-O-METHYL ETHER,PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA PHORBOL 12-N-METHYLANTHRANILATE PHORBOL 12-DECANOATE, 4BETA PHORBOL 12,13,20-TRIACETATE, 4BETA PHORBOL-12-MONOMYRISTATE,phorbol-12-myristat PHORBOL 13-ACETATE,PHORBOL 13-MONOACETATE PHORBOL 13-MYRISTATE 4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE 12-deoxy-phorbol,20-acetate-13-isobutyrat PHORBOL 12-PHENYLACETATE 13-ACETATE 20-HOMOVANILLATE PHORBOL 12,13-DINONANOATE 20-HOMOVANILLATE 4-Α-PHORBOL-12,13-DIDECANOATE