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Iopanoic acid

Iopanoic acid 구조식 이미지
카스 번호:
96-83-3
상품명:
Iopanoic acid
동의어(영문):
colepax;win2011;Bilipac;cistobil;cholevid;COPANOIC;Iopanoic;Bilumbal;choladine;bilijodon
CBNumber:
CB0753539
분자식:
C11H12I3NO2
포뮬러 무게:
570.93
MOL 파일:
96-83-3.mol

Iopanoic acid 속성

녹는점
153 °C
끓는 점
529.1±50.0 °C(Predicted)
밀도
2.2567 (estimate)
저장 조건
2-8°C
산도 계수 (pKa)
4.8(at 25℃)
물리적 상태
neat
수용성
348.3mg/L(37 ºC)
Merck
14,5058
CAS 데이터베이스
96-83-3(CAS DataBase Reference)
EPA
Benzenepropanoic acid, 3-amino-.alpha.-ethyl-2,4,6-triiodo- (96-83-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 20/21/22
안전지침서 22-26-36/37/39
WGK 독일 1
RTECS 번호 NW5075000
유해 물질 데이터 96-83-3(Hazardous Substances Data)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:

Iopanoic acid MSDS


2-Ethyl-3-(3-amino-2,4,6-triiodophenyl)propionic acid

Iopanoic acid C화학적 특성, 용도, 생산

화학적 성질

Light Brown Solid

Originator

Telepaque,Winthrop,US,1952

용도

Iodopanoic Acid is an iodine-containing radiocontrast medium used in cholecystography. Iodopanoic Acid is a potent inhibitor of thyroid hormone release from thyroid gland.

용도

antiulcer

Manufacturing Process

(A) Preparation of α-Ethyl-m-Nitrocinnamic Acid: This acid is prepared from 100 g of m-nitrobenzaldehyde, 210 g of butyric anhydride and 73 g of sodium butyrate. The crude α-ethyl-m-nitrocinnamicacid is crystallized from ethanol giving about 105 g, MP 140° to 142°C. From the filtrates there may be isolated a small amount of a stereoisomer, which when pure melts at 105° to 106°C.
(B) Preparation of m-Amino-α-Ethylhydrocinnamic Acid: A mixture of 50 g of α-ethyl-m-nitrocinnamic acid, 9.1 g of sodium hydroxide, 600 cc of water and 5 teaspoons of Raney nickel catalyst is shaken at 32°C in an atmosphere ofhydrogen at an initial pressure of 450 psi until the calculated amount of hydrogen is absorbed. The filtered solution is acidified with hydrochloric acid, made basic with ammonium hydroxide and again acidified with acetic acid. Upon concentration of this solution, an oil separates which crystallizes upon standing, giving about 20 g, MP 60° to 68°C. Complete evaporation of the filtrate and extraction of the residue of inorganic salts with ether gives about 20 g of additional material, MP 54° to 59°C. Recrystallization of the combined product from benzene petroleum ether gives about 35 g of m-amino-α- ethylhydrocinnamic acid, MP 67° to 70°C.
(C) Preparation of β-(3-Amino-2,4,6-Triiodophenyll-α-Ethylpropionic Acid: A solution of 5.0 g of m-amino-α-ethylhydrocinnamic acid in 100 cc of water containing 5 cc of concentrated hydrochloric acid is added over a period of ? hour to a stirred solution of 3.2 cc of iodine monochloride in 25 cc of water and 25 cc of concentrated hydrochloric acid heated to 60°C. After addition is complete, the heating is continued for one hour longer at 60° to 70°C. A black oil separates which gradually solidifies.
The mixture is then cooled and sodium bisulfite added to decolorize. Recrystallization of the product from methanol gives about 8 g, MP 147° to 150°C. The β-(3-amino-2,4,6-triiodophenyl)-α-ethylpropionic acid may be purified further by precipitation of the morpholine salt from ether solution and regeneration of the free amino acid by treatment of a methanol solution of the morpholine salt with sulfur dioxide. The pure amino acid has the MP 155° to 156.5°C.

Therapeutic Function

Diagnostic aid (radiopaque medium)

Iopanoic acid 준비 용품 및 원자재

원자재

준비 용품


Iopanoic acid 공급 업체

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