Diacerein
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Diacerein 속성
- 녹는점
- 217-2180C
- 끓는 점
- 631.5±55.0 °C(Predicted)
- 밀도
- 1.491±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(적게), 메탄올(약간)에 용해됨
- 산도 계수 (pKa)
- 3.01±0.20(Predicted)
- 색상
- 밝은 노란색에서 노란색까지
- 수용성
- 240μg/L at 25℃
- Merck
- 14,2960
- InChIKey
- TYNLGDBUJLVSMA-UHFFFAOYSA-N
- LogP
- 3.126 (est)
- CAS 데이터베이스
- 13739-02-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | CB8781000 | ||
| HS 번호 | 29146990 | ||
| 독성 | rat,LD50,unreported,7500mg/kg (7500mg/kg),Drugs of the Future. Vol. 4, Pg. 445, 1979. |
Diacerein C화학적 특성, 용도, 생산
개요
Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.화학적 성질
Yellow Crystalline Solid용도
Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.Diacerein 준비 용품 및 원자재
원자재
준비 용품
Diacerein 공급 업체
글로벌( 529)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 |
gao490372054@gamil.com | China | 1250 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 961 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Diacerein 관련 검색:
알로에 에모딘
Meloxicam
4-ETHYL-3-HYDROXYBENZOIC ACID
Chrysophanic acid
3'-Acetoxyacetophenone
Diacerein
ANTHRAQUINONE-2-CARBOXYLIC ACID
4-FORMYL-3-HYDROXYBENZOIC ACID
3-ACETOXYBENZOIC ACID
4-Acetylbenzoic acid
1-methoxyanthraquinone
3-Methoxy-4-methylbenzoic acid
3-Hydroxy-4-methylbenzoic acid
Rhein
2-ANTHRACENECARBOXYLIC ACID
2-METHOXY-2'-METHYLBENZOPHENONE
2-ACETOXYBENZOPHENONE
3-ACETOXY-3'-METHOXYBENZOPHENONE