ChemicalBook
Chinese English Japanese Germany Korea

ALSTERPAULLONE

ALSTERPAULLONE 구조식 이미지
카스 번호:
237430-03-4
상품명:
ALSTERPAULLONE
동의어(영문):
NSC 705701;ALSTERPAULLONE;9-Nitropaullone;Alsterpaullone - CAS 237430-03-4 - Calbiochem;7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one;9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5)-ONE;9-NITRO-7,12-DIHYDROINDOLO-[3,2-D][1]BENZAZEPIN-6(5H)-ONE;9-nitro-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one
CBNumber:
CB0778141
분자식:
C16H11N3O3
포뮬러 무게:
293.28
MOL 파일:
237430-03-4.mol

ALSTERPAULLONE 속성

녹는점
>330℃
저장 조건
2-8°C
용해도
DMSO: soluble
물리적 상태
powder
색상
brown

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 3

ALSTERPAULLONE C화학적 특성, 용도, 생산

용도

Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agents for treatment of Parkinson disease.

용도

Alsterpaullone is a derivative of kenpaullone , an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Alsterpaullone has been used to inhibit the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.

효소 저해제

This cell-permeable GSK3b (FW = 293.28 g/mol; CAS 237430-03-4), also named NSC 705701 and 9-nitro-7,12-dihydroindolo[3,2-d][1]benzazepin- 6(5H)-one, targets cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3b potently, reversibly, and ATP competitively. Displays remarkable antitumor activity in vitro. Alsterpaullone inhibits growth of the colon cancer cell line HCT-116, with an IC50 in the nanomolar range. Target(s): cyclin-dependent kinase, or cyclin-dependent protein kinase 2/cyclin A, IC50 = 0.08 μM; glycogen synthase kinase 3b, or [tau protein] kinase; IC50 = 0.11 μM; lymphocyte kinase, IC50 = 0.47 μM; cyclin-dependent protein kinase 1/cyclin B, IC50 = 0.035 μM; cyclin-dependent protein kinase 5/p25; mitogen-activated protein kinase; protein kinase C, weakly inhibited; cAMP-dependent protein kinase, or protein kinase A; weakly inhibited; non-specific serine/threonine protein kinase; protein-tyrosine kinase, or non-specific protein-tyrosine kinase, Lck protein-tyrosine kinase.

ALSTERPAULLONE 준비 용품 및 원자재

원자재

준비 용품


ALSTERPAULLONE 공급 업체

글로벌( 34)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13010 57
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
020-39119999 isunpharm@qq.com, isunpharm@hotmail.com China 3637 55
Sigma-Aldrich 021-61415566 800-819-3336(Tel) 400-620-3333(Mobile)
orderCN@merckgroup.com China 34131 80
Tcichem, Inc. 13918644899
- tianchong009@hotmail.com China 1613 55
Henan Alfachem Co.,Ltd. 18137891487;0371-55051623;QQ2853979817
-0371-63486673 2853979817@qq.com China 7020 58
Hangzhou Guangyuan Biotechnologies Co.,LTD 18989848203
services@raystarbio.com China 6963 58
Shenzhen Xinyaoxiong Industrial Co. Ltd. 0755-33204565 Sales QQ:2280077800(WeChat)
Advantage suppliers add cooperation QQ:577116998 szxys126@126.com China 54472 58

Copyright 2019 © ChemicalBook. All rights reserved