베라트라민
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베라트라민 속성
- 녹는점
- 122-1240C
- 알파
- D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol)
- 끓는 점
- 529.83°C (rough estimate)
- 밀도
- 1.0393 (rough estimate)
- 굴절률
- 1.6400 (estimate)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(최대 12mg/ml) 또는 에탄올(최대 10mg/ml)에 용해됩니다.
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 14.82±0.60(Predicted)
- 색상
- 갈색을 띤 노란색
- 최대 파장(λmax)
- 268nm(lit.)
- Merck
- 14,9952
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 60-70-8
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) | UN 2811 6.1/PG III | ||
---|---|---|---|
RTECS 번호 | YX5094000 | ||
HS 번호 | 2933.39.4100 | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
유해 물질 데이터 | 60-70-8(Hazardous Substances Data) |
베라트라민 C화학적 특성, 용도, 생산
개요
This alkaloid occurs naturally in Veratrum grandi/lorum and V. viride and is also formed during the hydrolysis of Veratrosine (q.v.). It forms colourless crystals of the monohydrate from aqueous EtOH and has [α]19D - 70° (MeOH). The hydrochloride forms colourless plates from EtOH, m.p. 20l-2°C and the picrate, yellow plates, m.p. 217.5 - 218°C. Two non-phenolic hydroxyl groups and an imino group are present and the triacetyl derivative, m.p. 205.5-206°C; [α]14.5D + 37.8° (MeOH), on controlled hydrolysis furnishes the N-acetyl com_x0002_pound, m.p. 176-8°C. The O-acetate has also been prepared as colourless prisms from aqueous EtOH, m.p. 20l-2°C but it is still uncertain which of the hydroxyl groups is acetylated in this derivative. Treatment with methyl iodide in MeOH in the presence of sodium carbonate gives N-methylveratraminc methiodide, m.p. 268°C (dec.) from which the methochloride, m.p. 277°C can be obtained. On catalytic hydrogenation, the base furnishes the dihydro derivative, m.p. 198- 200°C; [α]27D + 27.4°, which forms the N-acetyl compound, m.p. 220-3°C; [α]28D + 81° and the triacetyl derivative, m.p. l89.5-190.5°C; [α]24D + 84°.화학적 성질
White Solid용도
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer. Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM. Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.정의
ChEBI: A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.참고 문헌
Saito., Bull. Chem. Soc., Japan, 15, 22 (1940)Jacobs, Craig.,J. Biol. Chem., 155,565 (1944)
Jacobs,.Craig., ibid, 160,555 (1945)
Tamm, Wintersteiner., J. Amer. Chem. Soc., 74,3842 (1952)
Mass spectra: Budzikiwicz., Tetrahedron, 20,2267 (1964)
Synthesis: Masamune, Takasugi, Murai., Tetrahedron, 27,3369 (1971)
베라트라민 준비 용품 및 원자재
원자재
준비 용품
베라트라민 공급 업체
글로벌( 160)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
베라트라민 관련 검색:
폭심 베라트라민
2-(4-BIPHENYL)ETHYLAMINE
3,4-DIMETHYLPHENETHYLAMINE
Benzeneethanamine, -alpha--ethyl-3-methyl-
3-(4-ISOBUTYL-PHENYL)-PROPAN-1-OL
4-(2,4-DIMETHYLPHENYL)-1-BUTENE
2-(4-METHYLBENZYL)PIPERIDINE
2-[4-(2-CYCLOHEXYL-ETHYL)-PHENYL]-ETHYLAMINE
trimethylcumene
1,4-DI-ISO-PROPYL-2-METHYLBENZENE
1-(4-METHYL-PHENYL)-2-BUTANAMINE
VERATROSINE
Amfepentorex
3-(4-ISOPROPYL-PHENYL)-PROPAN-1-OL
1-(3-METHYLPHENYL)-4-METHYL-3-PENTENE
2-(3-METHYLBENZYL)PIPERIDINE
RARECHEM AN KB 0358