An isopropyl derivative of isoniazid that was
found to have mood-elevating effects in tuberculosis patients.
It was later found to be a monoamine oxidase (MAO) inhibitor
and, although not currently approved for clinical use as an
antidepressant due to its propensity to cause liver damage it
led to the development of other MAO inhibitors currently in
use. In addition to hepatotoxic effects, iproniazid is a hypotensive
agent and can cause potentially hazardous reactions with
other drugs and amine-rich foods.
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
iproniazid C화학적 특성, 용도, 생산
용도
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
World Health Organization (WHO)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was
introduced in 1952 for the treatment of depressive illness. Subsequently concern
regarding potentially serious interactions between MAOIs and foods containing
tyramine inspired much restrictive regulatory action. However, MAOIs still retain a
place in the treatment of serious depressive illness although there is no
international consensus on which compounds should be preferred. Thus iproniazid
remains available in several countries.
Purification Methods
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.
