Milbemycin oxime

Milbemycin oxime 구조식 이미지
카스 번호:
129496-10-2
상품명:
Milbemycin oxime
동의어(영문):
Milbemite;Mibemycin oxime;Milbemycin oxime;Milbemycin oxime CRS;β-phenylacrylophenone;Milbemycin Oxime (200 mg);Milbemycin Oxime (1443806);Sodium Pyrithione 3811-73-2;Milbemycin, oxime (9CI, ACI);Milbemycin Oxime (Mixture of Milbemycin Oxime A3 and A4)
CBNumber:
CB11104418
분자식:
2C32H45NO7.2C31H43NO7
포뮬러 무게:
2194.78
MOL 파일:
129496-10-2.mol
MSDS 파일:
SDS

Milbemycin oxime 속성

녹는점
169.6-177.4°
인화점
412℃
저장 조건
Store at -20°C
용해도
DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
물리적 상태
결정성 고체
안정성
흡습성
InChIKey
LKMMLHTWKLEARD-MGZQXKBQSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
유엔번호(UN No.) 2588
WGK 독일 3
위험 등급 6.1(b)
포장분류 III
HS 번호 2932206000
독성 LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy)
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 GHS hazard pictograms P273, P391, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P391 누출물을 모으시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
3 0

Milbemycin oxime C화학적 특성, 용도, 생산

용도

Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.

Clinical Use

Milbemycin oxime (Milbemycin) is available as an oral chewable tablet (2.3–27 mg) for heartworm prevention in dogs and cats, as well as a 0.1% otic solution for treating ear mites. It is not available in a more concentrated dosage form, so overdoses are relatively rare[1].

Veterinary Drugs and Treatments

Milbemycin tablets are labeled as a once-a-month heartworm preventative (Dirofilaria immitis) and for hookworm control (Ancylostoma caninum). It has activity against a variety of other parasites, including adult hookworms (A. caninum), adult roundworms (T. canis, T. leonina) and whipworms (Trichuris vulpis). In cats, milbemycin has been used successfully to prevent larval infection of Dirofilaria immitis.
Milbemycin, like ivermectin can be used for treatment of generalized demodicosis in dogs, but treatment can be significantly more expensive. It is likely safer to use in breeds susceptible to mdr1 genetic mutation (Collies, Shelties, Australian shepherds, etc.) at the doses used for this indication, but neuro toxicity is possible. Older dogs, those that have had a long duration of disease prior to treatment, and dogs with pododemodicosis appear have a lower success rate with milbemycin treatment.

Milbemycin oxime 준비 용품 및 원자재

원자재

준비 용품


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