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Fudosteine

Fudosteine 구조식 이미지
카스 번호:
13189-98-5
상품명:
Fudosteine
동의어(영문):
FUDESTEINE;FUDOSTEINE;Fudosteine99%;Fudosteine-d6 HCl;S-(3-HYDROXYPROPYL)CYSTEINE;s-(3-hydroxypropyl)-l-cystein;s-(3-hydroxypropyl)-l-cysteine;FUDOSTEINE(SUBJECTTOPATENTFREE);3-((3-hydroxypropyl)thio)-alanin;3-[(3-Hydroxypropyl)thio]alanine
CBNumber:
CB1128341
분자식:
C6H13NO3S
포뮬러 무게:
179.24
MOL 파일:
13189-98-5.mol

Fudosteine 속성

녹는점
200-202°C (dec.)
저장 조건
-20°C Freezer
CAS 데이터베이스
13189-98-5(CAS DataBase Reference)

안전

Fudosteine C화학적 특성, 용도, 생산

개요

Fudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic acid in sputa, so exhibiting mucoregulatory properties. In another study with SO2-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature increased by SO2, partly due to scavenging of superoxide anion.

화학적 성질

Off-White Powder

Originator

SS Pharmaceutical/Mitsubishi Pharma (Japan)

용도

An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.

용도

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment

용도

An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.

용도

A demonstrated antiinflammatory

용도

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.

상표명

Cleanal

위험도

A reproductive hazard.

Fudosteine 준비 용품 및 원자재

원자재

준비 용품


Fudosteine 공급 업체

글로벌( 173)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21830 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 2566 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23957 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hubei xin bonus chemical co. LTD
13657299721
zhangyuzhu@xhlchem.com CHINA 17425 58

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