VERATRIDINE
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VERATRIDINE 속성
- 녹는점
- 180℃
- 알파
- D20 +8.0° (ethanol)
- 끓는 점
- 689.74°C (rough estimate)
- 밀도
- 1.45±0.1 g/cm3 (20 ºC 760 Torr)
- 굴절률
- 1.6630 (estimate)
- 저장 조건
- -20°C
- 용해도
- 에탄올: 50mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.54(at 25℃)
- 색상
- 흰색에서 황백색까지
- Merck
- 13,10016
- BRN
- 78875
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 26/27/28-36/37/38-62-52/53-48/20 | ||
| 안전지침서 | 26-36/37/39-45-61-36/37-28 | ||
| 유엔번호(UN No.) | UN 1544 6.1/PG 1 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | YX5600000 | ||
| F 고인화성물질 | 10 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II | ||
| 유해 물질 데이터 | 71-62-5(Hazardous Substances Data) | ||
| 독성 | LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka) |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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VERATRIDINE C화학적 특성, 용도, 생산
개요
This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is almost certainly identical with the amorphous veratrine isolated by Schmidt and Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder which melts over a wide range. It has [α]22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes orange-red and eventually crimson with a blue fluorescence while that in HCI is colourless. Alkaline hydrolysis furnishes veratric acid and cevine.용도
Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.?This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.일반 설명
Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.Purification Methods
It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]참고 문헌
Merck., Annalen, 95, 200 (1855)Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)
VERATRIDINE 준비 용품 및 원자재
원자재
준비 용품
VERATRIDINE 공급 업체
글로벌( 90)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 |
cherry@crovellbio.com | China | 18457 | 58 |
VERATRIDINE 관련 검색:
아세트산 옥타데실아민 1,4-시클로헥산디메탄올 L-멘톨 2,5-디메틸-2,5-헥산디올 프로토카테츄산 에틸 에스테르 파라옥시안식향산이소프로필 1,2,7,8-옥탄테트롤
Verteporfin >=94% (HPLC)
1-Piperidinepropanol
ETHYL 3,4-DIMETHOXYBENZOATE
4-Hydroxy-3-methylpiperidine
PERHYDROFLUORENE
VERATRIDINE
Pinacol
N-ETHYL-4-HYDROXYPIPERIDINE
N, N-DIMETHYLOCTADECYLAMINE ACETATE
VERATRIDINE(RG)
VERATRINE