아미트립티린
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아미트립티린 속성
- 녹는점
- 196-197°C
- 끓는 점
- 410.26°C (rough estimate)
- 밀도
- 0.9415 (rough estimate)
- 굴절률
- 1.7500 (estimate)
- 저장 조건
- Store at -20°C
- 물리적 상태
- Liquid
- 산도 계수 (pKa)
- 9.4(at 25℃)
- 색상
- Colorless to light yellow
- 수용성
- 9.7mg/mL
- 안정성
- 감광성
- CAS 데이터베이스
- 50-48-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험 등급 | IRRITANT | ||
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유해 물질 데이터 | 50-48-6(Hazardous Substances Data) |
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신호 어: | Danger | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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아미트립티린 C화학적 특성, 용도, 생산
용도
Amitriptyline is used for anxious-depressive conditions. It is easier to tolerate than imipramine.정의
ChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.World Health Organization (WHO)
Amitriptyline, a tricyclic antidepressant was introduced in 1961 for the management of endogenous depression and is listed in the 8th WHO Model List of Essential Drugs. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led the Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.Biological Functions
Amitriptyline is a tertiary amine dibenzocycloheptadiene TCA with a propylidene side chain extending from the central carbocyclic ring. The diarylpropylideneamine moiety for amitriptyline makes it sensitive to photo-oxidation; therefore, its hydrochloride solutions should be protected from light to avoid ketone formation and precipitation.Pharmacokinetics
Amitriptyline is rapidly absorbed from the GI tract and from parenteral sites.Amitriptyline and its active metabolite, nortriptyline, are distributed into breast milk. Amitriptyline is primarily (65%) metabolized by N-demethylation by CYP2D6 to nortriptyline and hydroxylation to its E-10-hydroxy metabolite. Nortriptyline is pharmacologically active as a secondary amine TCA. Amitriptyline shows approximately equal affinity for 5-HT and NE transporters.아미트립티린 준비 용품 및 원자재
원자재
준비 용품
아미트립티린 공급 업체
글로벌( 98)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23555 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 |
mcbio_sales@163.com | China | 2255 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
아미트립티린 관련 검색:
다이메틸 프탈레이트 에탄 디메틸 에테르 다이메틸 푸마르산 N,N-다이메틸폼아마이드 프로판 다이메틸 설폭사이드 디메틸 카보네이트 디메틸설페이트 사이클로헵텐 1,3,5-시클로헵타트리
Dacthal
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
Amitriptyline Related Compound A
PIROHEPTINE
Cotriptyline
D/L-AMPHETAMINE HYDROCHLORIDE
AMITRIPTYLINE HYDROCHLORIDE, PHARMA,AMITRIPTYLINE HCL,AMITRIPTYLINE HYDROCHLORIDE,sk-amitriptylin