피리미돈
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피리미돈 속성
- 녹는점
- 281-282°C
- 끓는 점
- 358.94°C (rough estimate)
- 밀도
- 1.1402 (rough estimate)
- 굴절률
- 1.6660 (estimate)
- 인화점
- 9℃
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 물에는 매우 약간 용해되고, 에탄올에는 약간 용해됩니다(96%). 알칼리성 용액에 용해됩니다.
- 산도 계수 (pKa)
- 12.26±0.40(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 19ºC에서 <0.1g/100mL
- Merck
- 14,7746
- BCS Class
- 2
- InChIKey
- DQMZLTXERSFNPB-UHFFFAOYSA-N
- CAS 데이터베이스
- 125-33-7(CAS DataBase Reference)
- NIST
- Primidone(125-33-7)
- IARC
- 2B (Vol. 108) 2016
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-40-39/23/24/25-23/24/25-11 | ||
안전지침서 | 22-36-45-36/37-16-7 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UV9100000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29335990 | ||
유해 물질 데이터 | 125-33-7(Hazardous Substances Data) | ||
독성 | child,TDLo,oral,625mg/kg (625mg/kg),BEHAVIORAL: SLEEPBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: GENERAL ANESTHETIC,British Medical Journal. Vol. 1, Pg. 90, 1957. | ||
기존화학 물질 | KE-13609 |
피리미돈 C화학적 특성, 용도, 생산
개요
Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on C2 is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects.화학적 성질
Crystalline Solid용도
Primidone is mainly used for major attacks.정의
ChEBI: A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.일반 설명
Odorless white crystalline powder. Slightly bitter taste. No acidic properties.공기와 물의 반응
Insoluble in water.반응 프로필
Primidone is an amide. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to form flammable gases. A very weak base. The Combustion generates toxic mixed oxides of nitrogen (NOx).화재위험
Flash point data for Primidone are not available; however, Primidone is probably combustible.생물학적 활성
Anticonvulsant.Clinical Use
Primidone is the 2-deoxy derivative of phenobarbital and is approved by the U.S. FDA for initial or adjunctive treatment of simple partial, complex partial, and tonic-clonic seizures. It is less effective against these types of seizures than is phenytoin or CBZ, and it shares the antiseizure and sedative actions of phenobarbital. Although not approved for the purpose, it often is used to treat benign familial tremor (essential tremor).부작용
As with phenobarbital, serious toxicity for primidone is rare, although it may cause disabling sedation, irritability, and decreased mental functioning in a number of persons. Ataxia, dysphoria, idiosyncratic rash, leukopenia, agranulocytosis, lymphadenopathy, hepatitis, and a systemic lupus erythematosus–like syndrome have been reported adverse effects for primidone. Deficiencies of folic acid and of vitamins D and K are possible with long-term therapy of primidone, as is a folateresponsive megaloblastic anemia. Measurement of the complete blood cell count should be performed at 6-month intervals.Safety Profile
Poison by ingestion and intraperitoneal routes. Human teratogenic effects include developmental abnormalities of the craniofacial area, skin and skin appendages, and cardlovascular system. Human reproductive effects: effects on newborn, including unusual growth statistics, drug dependence, physical and other neonatal changes. Experimental teratogenic and reproductive effects. Human mutation data reported. An addictive drug. When heated to decomposition it emits toxic fumes of NOx. See also BARBITURATES.피리미돈 준비 용품 및 원자재
원자재
준비 용품
피리미돈 공급 업체
글로벌( 282)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9116 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15745 | 58 |