헥사메틸포스포릭트리아미드
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헥사메틸포스포릭트리아미드 속성
- 녹는점
- 7 °C (lit.)
- 끓는 점
- 230-232 °C/740 mmHg (lit.)
- 밀도
- 1.03 g/mL at 25 °C (lit.)
- 증기 밀도
- 6.18 (vs air)
- 증기압
- 0.07 mm Hg ( 25 °C)
- 굴절률
- n
20/D 1.459(lit.)
- 인화점
- 222 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 클로로포름, 메탄올(약간)에 용해됨
- 산도 계수 (pKa)
- 4.69±0.70(Predicted)
- 물리적 상태
- 액체
- 색상
- 무색~담황색 액체
- 냄새
- 매운 냄새(임계값 데이터 없음)
- 수용성
- 혼용 가능
- 어는점
- 7℃
- Merck
- 14,4725
- BRN
- 1099903
- Dielectric constant
- 30.0(20℃)
- 안정성
- 안정적인. 강산, 강산화제와 호환되지 않습니다.
- InChIKey
- GNOIPBMMFNIUFM-UHFFFAOYSA-N
- CAS 데이터베이스
- 680-31-9(CAS DataBase Reference)
- IARC
- 2B (Vol. 15, Sup 7, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
---|---|---|---|
위험 카페고리 넘버 | 45-46 | ||
안전지침서 | 53-45-99 | ||
유엔번호(UN No.) | 2810 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TD0875000 | ||
F 고인화성물질 | 8 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29299090 | ||
유해 물질 데이터 | 680-31-9(Hazardous Substances Data) | ||
독성 | LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines) | ||
기존화학 물질 | KE-18618 |
헥사메틸포스포릭트리아미드 C화학적 특성, 용도, 생산
화학적 성질
colourless or light amber liquid with an aromatic spicy odour용도
Hexamethylphosphoramide is a dipolar co-solvent and an effective additive used in reactions like reduction of halides, deoxygenation of sulfones, halide olefin couplings and cleavage of carbon-sulfur bond.일반 설명
Clear colorless to light amber liquid with a spicy odor.공기와 물의 반응
Water soluble.반응 프로필
Hexamethylphosphoramide may react with strong oxidizing agents and strong acids . Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.위험도
Possible carcinogen. Toxic by skin contact. Combustible.건강위험
The acute toxicity of hexamethylphosphoramide is low. HMPA can cause irritation upon contact with the skin and eyes. Hexamethylphosphoramide has been found to cause cancer in laboratory animals exposed by inhalation and meets the criteria for classification as an OSHA "select carcinogen." Chronic exposure to HMPA can cause damage to the lungs and kidneys. Reproductive effects in male animals treated with hexamethylphosphoramide have been observed. HMPA should be regarded as a substance with poor warning properties.화재위험
Hexamethylphosphoramide is combustible.인화성 및 폭발성
Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.잠재적 노출
Hexamethylphosphoric triamide is a material possessing unique properties and is widely used as a solvent in small quantities, in organic and organometallic reactions in laboratories. This is the major source of occu pational exposure to HMPA in the United States. It is also used as a processing solvent in the manufacture of aramid fibers. HMPA has been evaluated for use as an ultraviolet light absorber or inhibitor in polyvinylchloride formulations; as an additive for antistatic effects; as a flame retardant; and as a deicing additive for jet fuels. Hexamethylphosphoric triamide has also been extensively investigated as an insect chemosterilant.Carcinogenicity
Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.저장
this compound should be handled only in a fume hood, using appropriate impermeable gloves and splash goggles to prevent skin and eye contact. Containers of this substance should be stored in secondary containers.운송 방법
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name RequiredPurification Methods
The industrial synthesis is usually by treatment of POCl3 with excess of dimethylamine in isopropyl ether. Impurities are water, dimethylamine and its hydrochloride. It is purified by refluxing over BaO or CaO at about 4mm pressure in an atmosphere of nitrogen for several hours, then distilled from sodium at the same pressure. The middle fraction (b ca 90o) is collected, refluxed over sodium under reduced pressure under nitrogen and distilled. It is kept in the dark under nitrogen, and stored in solid CO2. It can also be stored over 4A molecular sieves. Alternatively, it is distilled under vacuum from CaH2 at 60o and is crystallised twice in a cold room at 0o, seeding the liquid with crystals obtained by cooling in liquid nitrogen. After about two-thirds are frozen, the remaining liquid is drained off [Fujinaga et al. Pure Appl Chem 44 117 1975]. For tests of purity see Fujinaga et al. in Purification of Solvents, Coetzee Ed., Pergamon Press, Oxford, 1982. For efficiency of desiccants in drying HMPA see Burfield and Smithers [J Org Chem 43 3966 1978, Sammes et al. J Chem Soc, Faraday Trans 1 281 1986]. [Beilstein 4 IV 284.] CARCINOGEN.비 호환성
Incompatible (possibly violent reaction; fire and explosions) with oxidizers (chlorates, nitrates,peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.). Keep away from alkaline materials, chemi cally active metals, strong acids, strong bases.폐기물 처리
Excess hexamethylphosphoramide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.헥사메틸포스포릭트리아미드 준비 용품 및 원자재
원자재
준비 용품
4-클로로-2-히드록시벤즈알데히드
polyquinoxaline
4-Pyridyl acetone
1-(Boc-아미노)시클로프로판카르복실산
Ethyl 2-oxocyclopentylacetate
2-에틸-5-메틸티오펜
메틸(2-)헥사논산
4,6-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
2-(메탄올)티오펜
potassium dichromate-polyimide photopolymer
5-에틸-티오펜-2-카르복실산
5-(메틸설포닐)티오펜-2-카복실산
아지도트리메틸실란
2-페녹시프로피온산
4-BROMO-5-ETHYL-THIOPHENE-2-CARBALDEHYDE
1-Aminocyclopropanecarboxylic acid
Sertaconazole nitrate
1,3-시클로헥사디엔
5-(메틸티오)티오펜-2-카르복실산
2-(Trifluoromethyl)nicotinic acid
2-클로로메틸-3-메틸-4-(2,2,2-트리플루오로에톡시)피리딘염산염
4-다이메틸아미노피리딘
헥사메틸포스포릭트리아미드 공급 업체
글로벌( 538)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618553607090 |
1093908296@qq.com | China | 1672 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 2998 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Hangzhou Bayee Chemical Co., Ltd. | 0086-571-86990109 |
rachelhoo@bayeechem.com | China | 104 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
헥사메틸포스포릭트리아미드 관련 검색:
헥사메틸다이실라잔 N-(트리스(하이드록시메틸)메틸)글리신 헥사민 트리스(하이드록시메틸)아미노메탄 3-(디메틸아미노)프로필아민 포스핀(기체) 메타 인산 포스파미돈 헥사메틸포스포릭트리아미드
Hexafluorobisphenol A
Ammonium hexafluorophosphate
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
SODIUM METHACRYLATE
Hexamethylphosphoramide-d18
Hexamethylphosphorous triamide
HEXAMINE
hexamethylphosphoramide N-demethylase
HEXAMETHYLPHOSPHORAMIDE & TRI-O-CRESYLPHOSPHATE