Latanoprost
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Latanoprost 속성
- 알파
- D20 +31.57° (c = 0.91 in acetonitrile)
- 끓는 점
- 583.8±50.0 °C(Predicted)
- 밀도
- 1.093±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMSO: 자유롭게 용해됨
- 물리적 상태
- 기름
- 산도 계수 (pKa)
- 14.84±0.70(Predicted)
- 색상
- 옅은 노랑
- Merck
- 14,5376
- BCS Class
- 2
- InChIKey
- GGXICVAJURFBLW-RDSJPUOVSA-N
- CAS 데이터베이스
- 130209-82-4(CAS DataBase Reference)
Latanoprost C화학적 특성, 용도, 생산
개요
Xalatan was launched in Sweden, Switzerland and the US for the treatment of glaucoma. It can be synthesized, from the Corey lactone, using standard prostaglandin chemistry. Latanoprost is a PGF2α, analog that is more lipophilic thus is better able to penetrate the cornea. The (15R)-diastereomer has only 10% of the activity compared to the (15S)-diastereomer. It is a selective FP receptor agonist with little or no effect on the other prostanoid receptors. The antiglaucoma effects are the result of reduced intraocular pressure arising by increasing uveoscleral outflow with little or no effect on trabeculo-canalicular aqueous outflow and no effect on retinal vasculation or permeability of the blood-aqueous barrier. The topical application is sufficient for a single daily dosage and is well tolerated with no detectible conjunctival hyperaemia.화학적 성질
Light Yellow Thick Oil용도
Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.정의
ChEBI: A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.일반 설명
Latanoprost (Xalatan) is available as a 0.005% sterileophthalmic solution in a 2.5-mL dispenser bottle.Latanoprost is also marketed as a combination ophthalmicproduct with the β-adrenergic blocking agent, timolol,which apparently enhances IOP-lowering by decreasing theproduction of aqueous humor. Cautions and side effects aresimilar to those for other ophthalmic prostanoids.Safety Profile
A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.Latanoprost 준비 용품 및 원자재
원자재
5-(아세트아미도)-N,N'-비스(2,3-디히드록시프로필)-2,4,6-트리요도-1,3-벤젠디카르복스아미드
디사이클로헥실카르보디이미디
염화 리튬
트리스(하이드록시메틸)아미노메탄
요오드화이소프로필
트리에틸아민
세슘 탄소산
수산화칼륨
백금분
(+)-Diisopinocampheyl chloroborane
준비 용품
Latanoprost 공급 업체
글로벌( 554)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15394 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 |
kyra@quanjinci.com | China | 1534 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 260 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9312 | 55 |
Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 |
CHINA | 139 | 55 |
Latanoprost 관련 검색:
페닐 살리실산 클로로사이클로펜테인 시클로펜탄 사이클로펜틸브로마이드 프로판 디페닐에테르 페닐초산
LATANOPROST LACTONE DIOL
PHENYL VALERATE
CHLOROPHOSPHONAZO III
Prostaglandin E1
2'-Hydroxy-3-phenylpropiophenone
LATANOPROST (FREE ACID),LATANOPROST ACID
Solvent Red 43
Prostaglandin E2
Travoprost
Dorzolamide Hydrochloride
Latanoprost Epoxide (Mixture of isoMers)