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에탄올아민

에탄올아민
에탄올아민 구조식 이미지
카스 번호:
141-43-5
한글명:
에탄올아민
동의어(한글):
2-아미노에탄올;2-아미노에타놀;2-에타놀아민;글리시놀;아미노에타놀;콜올아민;2-히드록시에탄아민;2-히드록시에틸아민;모노에타놀아민;베타-아미노에타놀;베타-아미노에틸알코올;베타-에타놀아민;베타-히드록시에틸아민;에타놀,2-아미노-;에탄올아민;에틸올아민;모노에탄올아민;2-하이드록시에틸아민;콜라민
상품명:
Ethanolamine
동의어(영문):
MEA 90;Olamine;Kolamin;MEA-LCI;COLAMINE;GLYCINOL;H-GLY-OL;cholamine;H-GLYCINOL;NH2CH2CH2OH
CBNumber:
CB1218589
분자식:
C2H7NO
포뮬러 무게:
61.08
MOL 파일:
141-43-5.mol

에탄올아민 속성

녹는점
10-11 °C(lit.)
끓는 점
170 °C(lit.)
밀도
1.012 g/mL at 25 °C(lit.)
증기 밀도
2.1 (vs air)
증기압
0.2 mm Hg ( 20 °C)
굴절률
n20/D 1.454(lit.)
인화점
200 °F
저장 조건
Store at +15°C to +25°C.
용해도
Soluble in benzene, ether, carbon tetrachloride.
산도 계수 (pKa)
9.5(at 25℃)
물리적 상태
Liquid
색상
APHA: ≤15
Specific Gravity
1.012
상대극성
0.651
수소이온지수(pH)
12.1 (100g/l, H2O, 20℃)
폭발한계
3.4-27%(V)
수용성
miscible
감도
Air Sensitive & Hygroscopic
Merck
14,3727
BRN
505944
Henry's Law Constant
1.61(x 10-10 atm?m3/mol) at 20 °C (Bone et al., 1983)
노출 한도
TLV-TWA 3 ppm (~7.5 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 6 ppm (~15 mg/m3) (ACGIH); IDLH 1000 ppm (NIOSH).
안정성
Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic.
InChIKey
HZAXFHJVJLSVMW-UHFFFAOYSA-N
CAS 데이터베이스
141-43-5(CAS DataBase Reference)
NIST
Ethanolamine(141-43-5)
EPA
Ethanolamine (141-43-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,C
위험 카페고리 넘버 20/21/22-34-39/23/24/25-23/24/25-10-52/53
안전지침서 26-36/37/39-45-61
유엔번호(UN No.) UN 2924 3/PG 3
WGK 독일 1
RTECS 번호 KJ5775000
F 고인화성물질 8-10-23
자연 발화 온도 410 °C
TSCA Yes
위험 등급 8
포장분류 III
HS 번호 29221100
유해 물질 데이터 141-43-5(Hazardous Substances Data)
독성 LD50 orally in rats: 10.20 g/kg (Smyth)
기존화학 물질 KE-20493
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H226 인화성 액체 및 증기 인화성 액체 구분 3 경고
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H372 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴 특정 표적장기 독성 - 반복 노출 구분 1 위험 P260, P264, P270, P314, P501
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P284 호흡 보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P307+P311 노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P405 밀봉하여 저장하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
2
3 0

에탄올아민 C화학적 특성, 용도, 생산

물성

모노에탄올아민(MEA)은 에탄올아민 그룹에 속하는 제품으로, 특히 세탁제 및 세정제의 제조 시 자주 사용됩니다.
모노에탄올아민은 에틸렌 옥시드와 암모니아의 반응을 통해 제조됩니다. 그 반응 과정에서는 디에탄올아민과 트리탄올아민이 함께 생성되는데, 이 제품들도 HELM에 의해 판매됩니다. 이 에탄올아민들은 아민과 알코올 그룹에 속하는 화합물입니다. 따라서, 이들은 양쪽 그룹에 모두 반응할 수 있는 독특한 성질을 갖습니다. 즉, 알코올 형태에서 에탄올아민들은 흡습성을 가지며 에스터 합성이 가능하고, 아민 형태에서는 약염기성을 띠며 산과 반응하여 소금과 비누를 형성합니다. 모노에탄올아민의 사용은 대부분 이러한 특성을 기반으로 한 것입니다. 산업적 용도의 모노에탄올아민은 순수 형태(농도 > 99%) 또는 다양한 농도의 수용액으로 공급됩니다. HELM은 순수 제품과 다양한 농도를 모두 포괄한 광범위한 제품 범위를 갖추고 있습니다.

용도

모노에탄올아민이 사용되는 영역은 지역에 따라 차이가 있습니다. 하지만 일반적으로는 제조량의 큰 부분이 제조자에 의해 직접 에틸렌 아민의 제조를 위한 원료로 사용되고 있습니다. 모노에탄올아민은 — 수용액 형태로 — 가스 세정(아민 세정) 시 흡수제로 자주 사용됩니다. 또한 모노에탄올아민은 목초 방부제 제조 시 그리고 세탁제 및 세정제의 계면활성제 제조 시의 화학적 중간 생성물이며, 염료 및 펄프 산업에서는 유기 용제로 사용됩니다. 그 외의 사용 영역에는 윤활제, 직물, 화장품 및 제약 성분의 제조가 포함됩니다.

개요

Monoethanolamine is contained in many products, such as metalwork fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.

화학적 성질

Monoethanolamine is a clear, colorless or pale yellow-colored, moderately viscous liquid with a mild, ammoniacal odor. Ethanolamines can be detected by odor as low as 2-3 ppm.

물리적 성질

Colorless, viscous, hygroscopic liquid with an unpleasant, mild, ammonia-like odor. Odor threshold concentration is 2.6 ppm (quoted, Amoore and Hautala, 1983). The lowest taste threshold concentration in potable water at 40 °C was 2.4 mg/L (Alexander et al., 1982).

용도

Monoethanolamine is used as a dispersing agent for agricultural chemicals, in thesynthesis of surface-active agents, as a softening agent for hides, and in emulsifiers,polishes, and hair solutions.

용도

As a chemical intermediate; corrosion inhibitor; in the production of cosmetics, detergents, paints, and polishes

용도

Used as buffer; removal of carbon dioxide and hydrogen sulfide from gas mixtures.

정의

ChEBI: A member of the class of ethanolamines that is ethane with an amino substituent at C-1 and a hydroxy substituent at C-2, making it both a primary amine and a primary alcohol.

생산 방법

Monoethanolamine is prepared commercially by the ammonolysis of ethylene oxide. The reaction yields a mixture of monoethanolamine, diethanolamine, and triethanolamine, which is separated to obtain the pure products. Monoethanolamine is also produced from the reaction between nitromethane and formaldehyde.

정의

ethanolamine: Any of three lowmeltinghygroscopic colourlesssolids. They are strong bases, smell ofammonia, and absorb water readilyto form viscous liquids. Monoethanolamine,HOCH2CH2NH2, is aprimary amine, m.p. 10.5°C; diethanolamine,(HOCH2CH2)2NH, is asecondary amine, m.p. 28°C; and triethanolamine,(HOCH2CH2)3N, is atertiary amine, m.p. 21°C. All aremade by heating ethylene oxide withconcentrated aqueous ammoniaunder pressure and separating theproducts by fractional distillation.With fatty acids they form neutralsoaps, used as emulsifying agentsand detergents, and in bactericidesand cosmetics.

일반 설명

A clear colorless liquid with an odor resembling that of ammonia. Flash point 185°F. May attack copper, brass, and rubber. Corrosive to tissue. Moderately toxic. Produces toxic oxides of nitrogen during combustion.

공기와 물의 반응

Water soluble with evolution of heat.

반응 프로필

Ethanolamine is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric acid, nitric acid, sulfuric acid, chlorosulfonic acid), acetic anhydride, acrolein, acrylonitrile, cellulose, epichlorohydrin, mesityl oxide, beta-propiolactone, vinyl acetate. Emits toxic fumes of nitrogen oxides when heated to decomposition [Sax, 9th ed., 1996, p. 1498].

건강위험

Monoethanolamine causes severe irritationof the eyes and mild to moderate irritationof the skin. The pure liquid caused rednessand swelling when applied to rabbits’ skin.The acute oral toxicity of this compound waslow in animals. The toxic symptoms includedsomnolence, lethargy, muscle contraction,and respiratory distress. The oral LD50 valuesshowed a wide variation with species.
LD50 value, oral (rabbits): 1000 mg/kg
Monoethanolamine showed reproductive tox icity when administered at a dose of850 mg/kg/day, causing 16% mortality topregnant animals (Environmental HealthResearch and Testing 1987). This study alsoindicated that monoethanolamine reduced thenumber of viable litters but had no effect onlitter size, the birth weight, or percentage sur vival of the pups.

화재위험

Special Hazards of Combustion Products: Irritating vapors generated when heated.

Pharmaceutical Applications

Monoethanolamine is used primarily in pharmaceutical formulations for buffering purposes and in the preparation of emulsions. Other uses include as a solvent for fats and oils and as a stabilizing agent in an injectable dextrose solution of phenytoin sodium.
Monoethanolamine is also used to produce a variety of salts with therapeutic uses. For example, a salt of monoethanolamine with vitamin C is used for intramuscular injection, while the salicylate and undecenoate monoethanolamine salts are utilized respectively in the treatment of rheumatism and as an antifungal agent. However, the most common therapeutic use of monoethanolamine is in the production of ethanolamine oleate injection, which is used as a sclerosing agent.

색상 색인 번호

Monoethanolamine is contained in many products, such as metalworking fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion, skin contact, subcutaneous, intravenous, and intramuscular routes. A corrosive irritant to skin, eyes, and mucous membranes. Human mutation data reported. Flammable when exposed to heat or flame. A powerful base. Reacts violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, cellulose, chlorosulfonic acid, epichlorohydrin, HCl, HF, mesityl oxide, HNO3, oleum, H2SO4, p-propiolactone, vinyl acetate. To fight fire, use foam, alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx. See also AMINES

Safety

Monoethanolamine is an irritant, caustic material, but when it is used in neutralized parenteral and topical pharmaceutical formulations it is not usually associated with adverse effects, although hypersensitivity reactions have been reported. Monoethanolamine salts are generally regarded as being less toxic than monoethanolamine.
LD50 (mouse, IP): 0.05 g/kg
LD50 (mouse, oral): 0.7 g/kg
LD50 (rabbit, skin): 1.0 g/kg
LD50 (rat, IM): 1.75 g/kg
LD50 (rat, IP): 0.07 g/kg
LD50 (rat, IV): 0.23 g/kg
LD50 (rat, oral): 1.72 g/kg
LD50 (rat, SC): 1.5 g/kg

잠재적 노출

Monoethanolamine is widely used in industry for scrubbing acid gases and in production of detergents and alkanolamide surfactants; to remove carbon dioxide and hydrogen from natural gas, to remove hydrogen sulfide and carbonyl sulfide; as an alkaline conditioning agent; as an intermediate for soaps, detergents, dyes, and textile agents. Diethanolamine is an absorbent for gases; a solubilizer for 2,4- dichlorophenoxyacetic acid (2,4-D); and a softener and emulsifier intermediate for detergents. It also finds use in the dye and textile industry. Triethanolamine is used as plasticizers, neutralizer for alkaline dispersions; lubricant additive; corrosion inhibitor; and in the manufacture of soaps, detergents, shampoos, shaving preparations; face and hand creams; cements, cutting oils, insecticides, surface active agents; waxes, polishes, and herbicides.

환경귀착

Biological. Bridié et al. (1979) reported BOD and COD values of 0.93 and 1.28 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. Similarly, Heukelekian and Rand (1955) reported a 5-d BOD value of 0.85 g/g which is 65.0% of the ThOD value of 1.31 g/g.
Chemical/Physical. Aqueous chlorination of ethanolamine at high pH produced Nchloroethanolamine, which slowly degraded to unidentified products (Antelo et al., 1981).
At an influent concentration of 1,012 mg/L, treatment with GAC resulted in an effluent concentration of 939 mg/L. The adsorbability of the carbon used was 15 mg/g carbon (Guisti et al., 1974).

신진 대사

Animal
Ethanolamine is a naturally occurring constituent in mammalian urine; the excretion rate is about 1.36 mg/kg/d for rats, 0.91 mg/kg/d for rabbits, and 0.454 mg/kg/d for cats (Luck and Wilcox 1953). It was suggested that deamination of ethanolamine occurs in vivo, since within 24 h after administration of [15N]-ethanolamine to rabbits, 40% of the [15N]-label was excreted as urea (Beard and Noe 1981). Sprinson and Weliky (1969) found that labeled ethanolamine was extensively converted to labeled acetate in rats.
Eight h after intraperitoneal injection of 0.52μmoles of [14C]-ethanolamine in Wistar rats, 11.5% of the injected dose was recovered as 14C02 (Taylor and Richardson 1967). At that time, about 50% of the injected radioactivity was found in the liver, and significant amounts (>2% [14C]/g tissue) were detected in the spleen and brain. In the liver, greater than 90% of the radioactivity was found in the lipid fraction; in the kidney, spleen and brain, the per cent in the lipid fraction was about 60, 30, and 54%, respectively. It was suggested that the main metabolic pathway for ethanolamine in rats involves its incorporation into phospholipids, presumably via exchange with serine in phosphatidylserine, resulting in the formation of phosphatidylethanolamine. The incorporation of [14C]-ethanolamine into ethanolamine phosphoglycerides in liver, heart and brain has been extensively studied and is thought to occur via the CDP-ethanolamine pathway or by a base exchange reaction (Ansell and Spanner 1967; Weinhold and Sanders 1971; Zelinski and Choy 1982).
Fifty h after topical application of [14C]-ethanolamine to excised pig skin in vitro (4μg/cm2), greater than 60% of the applied dose was found associated with the skin (Klain et al 1985). Twenty-four h after dermal application of [14C]- ethanolamine to athymic nude mice (4μg to 1.45 cm2), 19% of the applied dose was recovered in expired C02; this value was similar to that obtained after ip injection of ethanolamine. Radioactivity from [14C]ethanolamine was widely distributed in the body, with the highest levels found in the liver (26%) and kidneys (2.2%). Radioactivity was observed in hepatic phospholipids as the ethanolamine, serine, and choline bases, and in proteins and amino acids isolated from liver and skin sections. Urinary excretion included radioactive ethanolamine, urea, glycine, serine, uric acid, and choline. Thus, ethanolamine penetrates mouse skin and may be oxidized to C02, incorporated into hepatic phospholipids, or metabolized to amino acids.
Twenty-four h after administration of [14C]-ethanolamine to dogs, total radioactivity in the blood was 1.69% of the administered dse (Rhodes and Case 1977). Eleven % of the dose was excreted in the urine. The half-life of the persistent low level of radioactivity in the blood was 19 d.
Human
Ethanolamine is a naturally occurring constituent in human urine, with a mean excretion rate in males of 0.162 mg/kg/d and in females of 0.491 mg/kg/d (Luck and Wilcox 1953). [14C]-ethanolamine was topically applied to human skin grafted onto athymic nude mice at a dose of 4μg to a 1.45 cm2 graft area (Klain et al 1985). The rate and amount of radioactivity expired as 14C02 was similar to that described above for mice. Thus, the penetration rates of ethanolamine in human skin grafts and mouse skin appear to be similar.

저장

Monoethanolamine is very hygroscopic and is unstable when exposed to light. Aqueous monoethanolamine solutions may be sterilized by autoclaving.
When monoethanolamine is stored in large quantities, stainless steel is preferable for long-term storage. Copper, copper alloys, zinc, and galvanized iron are corroded by amines and should not be used for construction of storage containers. Ethanolamines readily absorb moisture and carbon dioxide from the air; they also react with carbon dioxide. This can be prevented by sealing the monoethanolamine under an inert gas. Smaller quantities of monoethanolamine should be stored in an airtight container, protected from light, in a cool, dry place.

운송 방법

UN2491 Ethanol amine or Ethanolamine solutions, Hazard class: 8; Labels: 8-Corrosive material.

비 호환성

Monoethanolamine contains both a hydroxy group and a primary amine group and will thus undergo reactions characteristic of both alcohols and amines. Ethanolamines will react with acids to form salts and esters. Discoloration and precipitation will take place in the presence of salts of heavy metals. Monoethanolamine reacts with acids, acid anhydrides, acid chlorides, and esters to form amide derivatives, and with propylene carbonate or other cyclic carbonates to give the corresponding carbonates.
As a primary amine, monoethanolamine will react with aldehydes and ketones to yield aldimines and ketimines. Additionally, monoethanolamine will react with aluminum, copper, and copper alloys to form complex salts. A violent reaction will occur with acrolein, acrylonitrile, epichlorohydrin, propiolactone, and vinyl acetate.

폐기물 처리

Controlled incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions

Regulatory Status

Included in parenteral and nonparenteral medicines licensed in the UK and USA. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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