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2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 구조식 이미지

카스 번호:: 102691-36-1

상품명:: 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

동의어(영문):: P-REAGENT;2-CYANOETHYL TETRAISOPROPYLPHOSPHORODIAMIDITE;3-Bis(diisopropylamino)phosphanyloxypropanenitrile;3-(bis(diisopropylamino)phosphinooxy)propanenitrile;THERAPEUTIC GRADE PHOS REAGENT;BIS(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINE;94.0%(GC&phosphordiamidit;Phosphorus reagent B;Phosphorous reagent A

CBNumber:: CB1231672

분자식:: C15H32N3OP

포뮬러 무게:: 301.41

MOL 파일:: 102691-36-1.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 410

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 속성

끓는 점: 100 °C0.5 mm Hg(lit.)

밀도: 0.949 g/mL at 25 °C(lit.)

굴절률: n20/D 1.470(lit.)

인화점: 141 °F

저장 조건: -20°C

용해도: Acetonitrile (Slightly), Benzene, Chloroform (Sparingly), Methanol (Slightly)

물리적 상태: 액체

산도 계수 (pKa): 6.78±0.70(Predicted)

색상: 무색의

감도: moisture sensitive, store cold

BRN: 3590103

안정성: 가열되면 폭발함

InChIKey: RKVHNYJPIXOHRW-UHFFFAOYSA-N

LogP: 4.04 at 20℃

CAS 데이터베이스: 102691-36-1(CAS DataBase Reference)

EPA: Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester (102691-36-1)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi,Xn
위험 카페고리 넘버	5-36/37/38-42/43-36/38
안전지침서	3-26-36-24/25-23-45-36/37
유엔번호(UN No.)	UN 1993 3/PG 3
WGK 독일	3
F 고인화성물질	10-21-34
위험 참고 사항	Irritant/May Explode on Heating
위험 등급	8
포장분류	I
HS 번호	29299000

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H226	인화성 액체 및 증기	인화성 액체	구분 3	경고
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H412	장기적 영향에 의해 수생생물에 유해함	수생 환경유해성 물질 - 만성	구분 3		P273, P501

예방조치문구:

P210	열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P233	용기를 단단히 밀폐하시오. 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 보관하시오.
P273	환경으로 배출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P303+P361+P353	피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.

NFPA 704

	2
1		0

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite C화학적 특성, 용도, 생산

개요

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is a colorless viscous liquid, which is soluble in most organic solvents. It is a widely used phosphitylating reagent for the preparation of various phosphorylated biomolecules, such as nucleoside carbohydrate conjugates, phospholipids and glycopeptides. In particular, this reagent is highly effective for automated solid-phase DNA/RNA oligonucleotide synthesis. It has shown great utility in the coupling of nucleobases or carbohydrates via their phosphotriesters in the presence of activators such as 1H-tetrazole, in moderate yields under mild conditions.This compound is cheaper and more stable than 2-cyanoethyl N,N-diisopropylchlorophosphorodiamidite (the other commonly used phosphinylating reagent)[1].

화학적 성질

Clear to Cloudy Colourless Liquid

용도

Reagent for synthesizing phosphitylated nucleotides.1

주요 응용

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is an important organic reagent widely used in the preparation of modified and unmodified nucleoside phosphoramidites. Nucleoside phosphoramidites are ideal reagents for polymer-supported synthesis of oligonucleotides. The diisopropylamino leaving group is readily cleaved upon contact with the azole catalyst, resulting in an efficient coupling reaction with the free hydroxyl group on the protected nucleoside.

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 준비 용품 및 원자재

원자재

5'-AMINO-5'-DEOXYTHYMIDINE BIS(DIISOPROPYLAMINO)CHLOROPHOSPHINE 2-CYANOETHYL PHOSPHORODICHLORIDITE 다이아이소프로필아민

준비 용품

Ceftibuten anionic starch DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE) DMT-dG(dmf) Phosphoramidite Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-(1,7-octadiyn-1-yl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], (S)- (9CI) DMT-dA(bz) Phosphoramidite 3'-DA CEP 5'-DMT-3'-O-TBDMS-N1-Me-Pseudouricdine-CE-Phosphoramidite 4-THIO-DU CEP (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE DMT-2'O-Methyl-rU Phosphoramidite

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 공급 업체

글로벌( 410)공급 업체

공급자	전화	이메일	국가	제품 수	이점
XINXIANG RUNYU MATERIAL CO., LTD.	+86-13592593621; +8613592593621	sales@runvmat.com	China	407	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
SHANGHAI NOVRIBO BIOTECH	17821030819	June.Liu@Desano.com	China	73	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 관련 검색:

염화 N-(클로로메틸렌)-N-메틸메탄아미늄 (1:1) 다이에톡시메테인 에톡시퀸 포스핀(기체) 에틸렌시아노히드린 Lithium diisopropylamide Ethoxymethylenemalononitrile LITHIUM PERIODATE BLOCKING REAGENT GE 4-Ethoxyphenol Bis(4-tert-butylcyclohexyl) peroxydicarbonate Bis(4-chlorobenzyl) azodicarboxylate (3R,5S)-3,5-DiMethylMorpholine hydrochloride Bis(2-methyl-3-furyl)disulfide Bis[3-(triethoxysilyl)propyl]tetrasulfide Bis(triethoxysilylpropyl) disulfide N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos Diisopropylamine