(+)-Pilocarpine hydrochloride
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(+)-Pilocarpine hydrochloride 속성
- 녹는점
- 202-205 °C(lit.)
- 알파
- 89 º (C=5, H2O)
- 저장 조건
- 2-8°C
- 용해도
- H2O: 100 mg/mL
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 녹는
- 감도
- Hygroscopic
- Merck
- 14,7424
- BRN
- 4034491
- 안정성
- 흡습성
- LogP
- -0.095 (est)
- CAS 데이터베이스
- 54-71-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
| 위험품 표기 | T+,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 26/28-25-23 | ||
| 안전지침서 | 25-45 | ||
| 유엔번호(UN No.) | UN 1544 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | TK1450000 | ||
| F 고인화성물질 | 3-8-10 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 29399990 |
(+)-Pilocarpine hydrochloride C화학적 특성, 용도, 생산
화학적 성질
Crystalline Solid용도
(+)-Pilocarpine hydrochloride is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.일반 설명
Pilocarpine monohydrochlorideis the hydrochloride of an alkaloid obtainedfrom the dried leaflets of Pilocarpus jaborandi or P. microphyllus,in which it occurs to the extent of about 0.5% togetherwith other alkaloids.생물학적 활성
Muscarinic agonist.Clinical Use
Pilocarpine, the salt of an alkaloid obtained from Pilocarpus jaborandi, is an example of a muscarinic agonist that does not adhere to the traditional SAR. In 1876, Langley reported that extracts containing the alkaloid stimulated the end organs of parasympathetic neurons. The structure of pilocarpine was reported in 1901.Pilocarpine is marketed as tablets (Salogen), an ophthalmic solution, and gel. It penetrates the eye well and is the miotic of choice for open-angle glaucoma and to terminate acute angle closure attacks. It also is used for the treatment of xerostomia (dryness of the mouth) caused by radiation therapy of the head and neck, Sjogren's syndrome, or as a side effect of some psychotropic drugs.
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects: cardiac changes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PILOCARPINE.(+)-Pilocarpine hydrochloride 준비 용품 및 원자재
원자재
4-다이메틸아미노피리딘
염산
디이소부틸알루미늄하이드라이드
Palladium hydroxide
수소화나트륨
2(3H)-Furanone, 3-ethylidenedihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (4R)-
준비 용품
(+)-Pilocarpine hydrochloride 공급 업체
글로벌( 268)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Eaglech（shanghai）Pharmaceutical Co., Ltd | +8613884467586 |
info@distant-chem.com | China | 10 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |