니칼디핀 수화염화물
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니칼디핀 수화염화물 속성
- 녹는점
- 176-1780C
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ~1mg/mL
- 물리적 상태
- 가루
- 색상
- 노란색
- Merck
- 14,6495
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. 증류수 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
- InChIKey
- AIKVCUNQWYTVTO-UHFFFAOYSA-N
- CAS 데이터베이스
- 54527-84-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/24/25 | ||
| 안전지침서 | 36/37/39-45 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | US7972100 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2933399090 | ||
| 독성 | LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado) | ||
| 기존화학 물질 | KE-10623 |
니칼디핀 수화염화물 C화학적 특성, 용도, 생산
개요
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).화학적 성질
Yellow Solid용도
Dihydropyridine calcium channel blocker. Antianginal; antihypertensive일반 설명
Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an니칼디핀 수화염화물 준비 용품 및 원자재
원자재
준비 용품
니칼디핀 수화염화물 공급 업체
글로벌( 317)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@airuikechemical.com | China | 994 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |