피퍼린
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피퍼린 속성
- 녹는점
- 131-135 °C(lit.)
- 끓는 점
- 427.77°C (rough estimate)
- 밀도
- 1.0864 (rough estimate)
- 굴절률
- 1.5400 (estimate)
- FEMA
- 2909 | PIPERINE
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 0.04g/L
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 12.22(at 18℃)
- 색상
- 황백색에서 황갈색 또는 노란색 황갈색
- 냄새
- 프로필렌 글리콜 중 1.00%. 고추 동물
- ?? ??
- 매운
- 수용성
- 40mg/L(18℃)
- Merck
- 14,7472
- JECFA Number
- 1600
- BRN
- 90741
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- MXXWOMGUGJBKIW-YPCIICBESA-N
- LogP
- 2.66
- CAS 데이터베이스
- 94-62-2(CAS DataBase Reference)
- NIST
- Piperine(94-62-2)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi,N | ||
---|---|---|---|
위험 카페고리 넘버 | 22-21/22-20/21/22-51/53 | ||
안전지침서 | 22-24/25-36/37-36-61 | ||
유엔번호(UN No.) | UN 3077 9 / PGIII | ||
WGK 독일 | 3 | ||
RTECS 번호 | TN2321500 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29399990 | ||
독성 | LD50 orally in Rabbit: 514 mg/kg |
피퍼린 C화학적 특성, 용도, 생산
개요
Piperine is an alkaloid responsible for the taste and fl avor of pepper. In pure form it exists as a yellow to pale-yellow crystal, with a burning taste and pungent order. It is found naturally in plants in the Piperaceae family, particularly Piper nigrum (black pepper) and Piper longum (Indian long pepper). Piper nigrum is a perennial woody vine that grows to approximately 30 feet. It produces spikelike flowers that hold berries called peppercorns.화학적 성질
Piperine is odorless. It is tasteless at first, but develops a burning aftertaste of pepper.출처
Reported found in black pepper; also in Piper longum, Piper officinarum, Piper lowong BI., Piper famechoni, Piper chaba and the leaves of Rhododendron fauriae var. rupescens.역사
Hans Christian Oersted (1777 1851) isolated piperine from black pepper in 1819 and published his findings in 1820. Oersted extracted a resin from pepper plants with alcohol, formed a soluble saltby adding hydrochloric acid with alcohol, and then separated piperine from solution by precipitation and distillation. In 1882, Leopold Rügheimer (1850 1917) synthesized piperine from piperinic acid chloride and piperidine. The complete synthesis of piperine was reported in 1894 by Albert Ladenburg (1842 1911) and M. Scholtz. Ladenburg and Scholtz used piperonal (C8H6O3) and acetaldehyde (CH3CHO) to produce piperinic acid (C12H10O4), which was then reacted with thionyl chloride (COCl2) and piperidine (C5H11N) to produce piperine.용도
Piperine is used in granular formulations as a pesticide against small animals such as dogs, cats, skunks, raccoons, and squirrels. Piperine pesticides are nontoxic and operate as a repellant when animals smell or test them. Piperine is also incorporated with other compounds to make insecticides; it is effective against houseflies, lice, and various other pests.Piperine has been used medicinally for thousands of years and this continues today. It is used to treat asthma and chronic bronchitis. It also has putative analgesic and antiinfl ammatory properties that stem from its antioxidant properties. Research is examining the use of piperine in treating malaria. Antiepilepsirine is a derivative of piperine that is used to treat different types of epilepsy, especially in China. A current area of interest is the efficacy of piperine in increasing the bioavailability of certain nutrients and drugs. It is thought to possibly aid digestion and increase the absorption in the digestive tract of numerous drugs used as cancer treatments, antihistamines, steroidal inflammation reducers, and antibiotics.
제조 방법
From piperoyl chloride and piperidine.Safety Profile
Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.Purification Methods
Piperine crystallises as light yellow crystals from EtOH or EtOAc (m 132o), aqueous EtOH (m 128-129o), Et2O (m129o), or*benzene/ligroin. [Beilstein 20 H 79, 20 I 23, 20 II 53, 20 III/IV 1341, 20/3 V 469.]참고 문헌
Oersred., Schweigger's Journal, 29, 80 (1819)Fliickiger, Hanbury., Pharmacographica, 584 London (1879)
Stenhouse., Pharm. J., 14,363 (1855)
Cazeneuve, Caillot., Bull. Soc. Chim. Fr., 27,291 (1877)
Riigheimer., Ber., 15, 1391 (1882)
Peinemann., Arch. Pharm., 234, 245 (1896)
Newman., Chem. Products, 16,379 (1953)
피퍼린 준비 용품 및 원자재
원자재
준비 용품
피퍼린 공급 업체
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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career henan chemical co | +86-0371-86658258 |
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Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
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Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
sales@dolonchem.com | CHINA | 2972 | 58 |