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ChemicalBook >제품 카탈로그 >α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴
α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 구조식 이미지
카스 번호:
218136-59-5
한글명:
α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴
동의어(한글):
α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴
상품명:
α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
동의어(영문):
CS-117;SC 26196;PF-o6341724;SC26196;SC 26196;SC 26196 - PF 06341724;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine;a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;1-Piperazinepentanenitrile, α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-
CBNumber:
CB12518849
분자식:
C27H29N5
포뮬러 무게:
423.55
MOL 파일:
218136-59-5.mol

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 속성

저장 조건
2-8°C
용해도
DMSO: ≥10mg/mL
물리적 상태
가루
색상
흰색에서 황갈색까지
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
WGK 독일 3
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 C화학적 특성, 용도, 생산

개요

The enzyme Δ6 desaturase mediates the conversion of linoleic acid to γ-linolenic acid (GLA), which can then be elongated to dihomo-γ-linolenic acid (DGLA). DGLA can then be used as a substrate for Δ5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids. SC 26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 μM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 μM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA. SC 26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice. It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.

용도

A selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). It exhibits anti-inflammatory properties in a mouse edema model.

Biochem/physiol Actions

SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 준비 용품 및 원자재

원자재

준비 용품

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 공급 업체

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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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 trendseenbio@gmail.com China 11681 58

α,α-디페닐-4-[(3-피리디닐메틸렌)아미노]-1-피페라진펜탄니트릴 관련 검색:

Nicotinamide SC-43 SC-1 SC-560 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A SC 66
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