눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
4
0
1-프로판아민,3-(10,11-다이하이드로-5H-다이벤조(a,d)사이클로헵텐-5-일리덴)-N,N-다이메틸-,하이드로클로라이드 C화학적 특성, 용도, 생산
개요
Amitriptyline (hydrochloride) (CRM) (Item No. 19031) is a certified reference material categorized as a tricyclic antidepressant. This product is intended for analytical forensic applications. This product is also available as a general research tool .
화학적 성질
White to Off-White Solid
용도
Amitriptyline hydrochloride is a tricyclic antidepressant drug. Amitriptyline hydrochloride inhibits the norepinephrine and serotonin transporters but has a high affinity for α1-adrenergic, serotonin and muscarinic acetylcholine receptors.
일반 설명
Amitriptyline, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride,5-(3-dimethylaminopropylidene)-10,11-dihydro-5Hdibenzo[a,d]cycloheptene hydrochloride (Elavil), is one ofthe most anticholinergic and sedative of the TCAs. Becauseit lacks the ring-electron–enriching nitrogen atom ofimipramine, metabolic inactivation mainly proceeds not at theanalogous 2-position but at the benzylic 10-position (i.e.,toluene-like metabolism predominates). Because of the 5-exocyclic double bond, E- and Z-hydroxy isomers are producedby oxidation metabolism. Conjugation produces excretablemetabolites. As is typical of the dimethyl compounds,N-demethylation occurs, and nortriptyline is produced, whichhas a less anticholinergic, less sedative, and more stimulantaction than amitriptyline. Nortriptyline is a SNERI; thecomposite action of drug and metabolite is nonselective.
Safety Profile
Poison by ingestion,
intraperitoneal, intravenous, and
subcutaneous routes. Human systemic
effects by ingestion: convulsions, respiratory
depression, changes in sleep, hallucinations,
muscle contractions, somnolence, blood
pressure decrease, coma, cyanosis, dyspnea,
and ataxia. An experimental teratogen.
Other experimental reproductive effects.
Mutation data reported. Used in the
treatment of depression. When heated to
decomposition it emits very toxic fumes of
HCl and NOx. See also ELAVIL.
1-프로판아민,3-(10,11-다이하이드로-5H-다이벤조(a,d)사이클로헵텐-5-일리덴)-N,N-다이메틸-,하이드로클로라이드 준비 용품 및 원자재