PeraMpanel
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PeraMpanel 속성
- 끓는 점
- 619.1±55.0 °C(Predicted)
- 밀도
- 1.31±0.1 g/cm3(Predicted)
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 4.73±0.19(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
PeraMpanel C화학적 특성, 용도, 생산
개요
In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential. Parampanel was discovered through lead optimization of a commercially available compound, 2,4-diphenyl-4H-[1,3,4]oxadiazin-5-one, which was identified by high-throughput screening of a compound collection employing a rat cortical neuron AMPA-induced cell-death assay. Modifications of aromatic rings at positions 1, 3, and 5 while changing the core to pyridone led to parampanel which inhibited AMPA-induced calcium influx (IC50=60 nM). Parampanel had a minimum effective oral dose of 2 mg/kg in an AMPA-induced mouse seizure model. The synthesis of parampanel was accomplished via a 6-step route utilizing Suzuki–Miyaura couplings and modified Ullmann reactions for incorporation of aryl groups.용도
Isotope labelled Perampanel (P285520), is an antiepileptic drug. It inhibits α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-induced increases in intracellular Ca2+ and selectively blocks AMPA receptor-mediated synaptic transmission, thus reducing neuronal excitation.정의
ChEBI: A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.PeraMpanel 준비 용품 및 원자재
원자재
380917-96-4
6'-Methoxy-2,3'-bipyridine
5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE
2,5-Dibromopyridine
5-Bromo-2-methoxypyridine
준비 용품
PeraMpanel 공급 업체
글로벌( 159)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 288 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 |
dominicguo@gk-bio.com | CHINA | 9427 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 |
shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 |
2571773637@qq.com | China | 9821 | 58 |
PeraMpanel 관련 검색:
Tafluprost
Entacapone
Unii-4bmh7izt98
Levetiracetam
5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
2-(2-cyanophenyl)benzonitrile
2-Bromobenzonitrile
PRMWGUBFXWROHD-MYWHSQMISA-N
1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one
3,5-Dimethoxypyridine
Phenylboronic acid
2-Cyanophenylboronic acid
PeraMpanel
PeraMpanel
PeraMpanel
3,5-Dibromopyridine
6'-Methoxy-2,3'-bipyridine
PeraMpanel