ChemicalBook
Chinese English Japanese Germany Korea

프루메퀸

프루메퀸
프루메퀸 구조식 이미지
카스 번호:
42835-25-6
한글명:
프루메퀸
동의어(한글):
프루메퀸;프루메퀸(FLUMEQUINE)
상품명:
Flumequine
동의어(영문):
R 802;Apurone;Aoyribe;Imequyl;Fantacin;Flumural;Flumigal;FLUMEQUIN;Quinolone;FLUMEQUINE
CBNumber:
CB1264632
분자식:
C14H12FNO3
포뮬러 무게:
261.25
MOL 파일:
42835-25-6.mol

프루메퀸 속성

녹는점
253-255°C
끓는 점
439.7±45.0 °C(Predicted)
밀도
1.45±0.1 g/cm3(Predicted)
RTECS 번호
DK1672000
인화점
>110°(230°F)
저장 조건
Sealed in dry,Store in freezer, under -20°C
용해도
1 M NH4OH: soluble50mg/mL
산도 계수 (pKa)
pKa 6.42(H2O t=25.0 I=0.025)(Approximate)
물리적 상태
powder
색상
white to off-white
수용성
Soluble in DMSO and dilute alkali hydroxides. Insoluble in water
Merck
14,4137
BRN
490724
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
42835-25-6(CAS DataBase Reference)
EPA
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo- (42835-25-6)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 22-24/25-36/37/39-27-26
WGK 독일 3
F 고인화성물질 10
HS 번호 29339900
유해 물질 데이터 42835-25-6(Hazardous Substances Data)
기존화학 물질 KE-17022

프루메퀸 C화학적 특성, 용도, 생산

화학적 성질

White Crystalline Solid

Originator

Apurone,Riker,France,1977

용도

Inhibits topoisomerases in Gram-negative bacteria.

용도

vasodilator

용도

Fluorinated quinolone antibacterial

Manufacturing Process

6-Fluoro-2-methyltetrahydroquinoline (32.2 g, 0.2 mol) is mixed with diethyl ethoxymethylenemalonate, and the mixture is heated at 125°C to 130°C for 3 hours. Polyphosphoric acid (200 g) is added, and the solution is gradually heated to 115°C to 120°C in an oil bath with occasional stirring. The temperature is maintained for 1 hour, then the mixture is poured into 600 ml of water and neutralized with 40% sodium hydroxide solution. The product ester which precipitates is separated by filtration, washed with water and suspended in 2 liters of 10% sodium hydroxide solution. The mixture is heated on the steam bath for 1 hour, treated with decolorizing charcoal, filtered, then neutralized with concentrated hydrochloric acid. The solid product is isolated by filtration of the hot solution, washed with water and recrystallized from dimethylformamide.

Therapeutic Function

Antibacterial

Pharmaceutical Applications

A tricyclic fluorinated 4-quinolone, with activity similar to that of nalidixic acid in vitro, although it is somewhat more active against some Enterobacteriaceae.
Following escalating oral doses of 400, 800 or 1200 mg, mean peak plasma levels reached at 2 h are 13.5, 23.8 and 31.9 mg/L, respectively. The apparent elimination half-life is about 7 h. The main metabolite, hydroxyflumequine, is much more rapidly eliminated. About 60% of a dose appears in the urine, mostly in the form of conjugates. Urinary concentrations following an 800 mg dose are 10–35 mg/L, with a peak of 105 mg/L. It has no effect on the pharmacokinetics of theophylline.
Flumequine is generally well tolerated, side effects being mainly mild gastrointestinal tract disturbances, rashes, dizziness and confusion.
It is principally used in uncomplicated urinary tract infections.

프루메퀸 준비 용품 및 원자재

원자재

준비 용품


프루메퀸 공급 업체

글로벌( 301)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58

Copyright 2019 © ChemicalBook. All rights reserved