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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran 구조식 이미지

카스 번호:: 915095-94-2

상품명:: (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

동의어(영문):: EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene

CBNumber:: CB12657939

분자식:: C17H16ClIO2

포뮬러 무게:: 414.67

MOL 파일:: 915095-94-2.mol

속성

안전

용도

공급 업체 368

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran 속성

끓는 점: 476.0±45.0 °C(Predicted)

밀도: 1.578±0.06 g/cm3 (20 ºC 760 Torr)

저장 조건: 2-8°C(protect from light)

용해도: DMSO, 메탄올(약간 용해됨, 초음파 처리)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 흰색에서 황백색까지

InChI: InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1

InChIKey: YLUHNGIWRCCQMQ-INIZCTEOSA-N

SMILES: O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1

CAS 데이터베이스: 915095-94-2

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran C화학적 특성, 용도, 생산

개요

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

제조 방법

0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran 준비 용품 및 원자재

원자재

4-Hydroxybenzyl chloride 4-(2-chloro-5-iodobenzyl)phenol 2-Chloro-5-iodobenzoic acid 2-Chloro-5-iodo-benzoyl chloride Empagliflozin Impurity 35 (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 메톡시벤질클로라이드 4-Iodoaniline

준비 용품

1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran 공급 업체

글로벌( 368)공급 업체

공급자	전화	이메일	국가	제품 수	이점
SyncoZymes (Shanghai) Co., Ltd.,	+86-021-68187180-811 +86-13681683526	lchen@syncozymes.com	China	188	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Porton Pharma Solutions Ltd.			China	56	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	228	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran 관련 검색:

(S)-(+)-3-하이드록시 사하이드로 퓨란 (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran Dimethyl fumarate 1-Propanol (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Brexpiprazole Intermediate 1